Application of a Raney-cobalt-mediated tandem reductive cyclization protocol to total syntheses of the aspidosperma alkaloids (±)- limaspermidine and (±)-1-acetylaspidoalbidine

Shen H. Tan, Martin G. Banwell*, Anthony C. Willis, Tristan A. Reekie

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    57 Citations (Scopus)

    Abstract

    The racemic modification of the Aspidosperma alkaloid limaspermidine (1) has been prepared in ten steps including one involving a Raney-cobalt-mediated tandem reductive cyclization of nitrile 8 to give the tetracyclic system 9b. Compound (±)-1 has been converted over two steps into (±)-1-acetylaspidoalbidine [(±)-13].

    Original languageEnglish
    Pages (from-to)5621-5623
    Number of pages3
    JournalOrganic Letters
    Volume14
    Issue number22
    DOIs
    Publication statusPublished - 16 Nov 2012

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