Approaches to the neurotrophically active natural product 11-O-debenzoyltashironin: A chemoenzymatic total synthesis of the structurally related sesquiterpene khusiol

Mukesh K. Sharma; Martin G. Banwell; Anthony C. Willis; A. David Rae

doi:10.1002/asia.201100913

Approaches to the neurotrophically active natural product 11-O-debenzoyltashironin: A chemoenzymatic total synthesis of the structurally related sesquiterpene khusiol

Mukesh K. Sharma, Martin G. Banwell^*, Anthony C. Willis, A. David Rae

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Soothes your nerves: The enantiomerically enriched cis-1,2-dihydrocatechol 4 has been converted, over 16 steps including one involving an intramolecular Diels-Alder reaction, into the sesquiterpenoid natural product khusiol (3), which is structurally related to the neurite outgrowth-promoting natural product 11-O-debenzoyltashironin (1).

Original language	English
Pages (from-to)	676-679
Number of pages	4
Journal	Chemistry - An Asian Journal
Volume	7
Issue number	4
DOIs	https://doi.org/10.1002/asia.201100913
Publication status	Published - Apr 2012

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abstract = "Soothes your nerves: The enantiomerically enriched cis-1,2-dihydrocatechol 4 has been converted, over 16 steps including one involving an intramolecular Diels-Alder reaction, into the sesquiterpenoid natural product khusiol (3), which is structurally related to the neurite outgrowth-promoting natural product 11-O-debenzoyltashironin (1).",

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author = "Sharma, {Mukesh K.} and Banwell, {Martin G.} and Willis, {Anthony C.} and Rae, {A. David}",

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Approaches to the neurotrophically active natural product 11-O-debenzoyltashironin: A chemoenzymatic total synthesis of the structurally related sesquiterpene khusiol. / Sharma, Mukesh K.; Banwell, Martin G.; Willis, Anthony C. et al.
In: Chemistry - An Asian Journal, Vol. 7, No. 4, 04.2012, p. 676-679.

Research output: Contribution to journal › Article › peer-review

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AU - Willis, Anthony C.

AU - Rae, A. David

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AB - Soothes your nerves: The enantiomerically enriched cis-1,2-dihydrocatechol 4 has been converted, over 16 steps including one involving an intramolecular Diels-Alder reaction, into the sesquiterpenoid natural product khusiol (3), which is structurally related to the neurite outgrowth-promoting natural product 11-O-debenzoyltashironin (1).

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KW - synthetic methods

KW - terpenoids

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Approaches to the neurotrophically active natural product 11-O-debenzoyltashironin: A chemoenzymatic total synthesis of the structurally related sesquiterpene khusiol

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