Abstract
Given two sequences over a finite alphabet L, the D2 statistic is the number of m-letter word matches between the two sequences. This statistic is used in bioinformatics for expressed sequence tag database searches. Here we study a generalization of the D2 statistic in the context of DNA sequences, under the assumption of strand symmetric Bernoulli text. Fork < m, we look at the count of m-letter word matches with up to k mismatches. For this statistic, we compute the expectation, give upper and lower bounds for the variance and prove its distribution is asymptotically normal.
Original language | English |
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Pages (from-to) | 1-21 |
Number of pages | 21 |
Journal | Annals of Applied Probability |
Volume | 18 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 2008 |