Aryl-Fluoride Bond-Forming Reductive Elimination from Nickel(IV) Centers

Elizabeth A. Meucci; Alireza Ariafard; Allan J. Canty; Jeff W. Kampf; Melanie S. Sanford

doi:10.1021/jacs.9b06896

Aryl-Fluoride Bond-Forming Reductive Elimination from Nickel(IV) Centers

Elizabeth A. Meucci, Alireza Ariafard, Allan J. Canty, Jeff W. Kampf, Melanie S. Sanford^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

The treatment of pyridine- and pyrazole-ligated Ni^II σ-aryl complexes with Selectfluor results in C(sp²)-F bond formation under mild conditions. With appropriate design of supporting ligands, diamagnetic Ni^IV σ-aryl fluoride intermediates can be detected spectroscopically and/or isolated during these transformations. These studies demonstrate for the first time that Ni^IV σ-aryl fluoride complexes participate in challenging C(sp²)-F bond-forming reductive elimination to yield aryl fluoride products.

Original language	English
Pages (from-to)	13261-13267
Number of pages	7
Journal	Journal of the American Chemical Society
Volume	141
Issue number	33
DOIs	https://doi.org/10.1021/jacs.9b06896
Publication status	Published - 21 Aug 2019
Externally published	Yes

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abstract = "The treatment of pyridine- and pyrazole-ligated NiII σ-aryl complexes with Selectfluor results in C(sp2)-F bond formation under mild conditions. With appropriate design of supporting ligands, diamagnetic NiIV σ-aryl fluoride intermediates can be detected spectroscopically and/or isolated during these transformations. These studies demonstrate for the first time that NiIV σ-aryl fluoride complexes participate in challenging C(sp2)-F bond-forming reductive elimination to yield aryl fluoride products.",

author = "Meucci, {Elizabeth A.} and Alireza Ariafard and Canty, {Allan J.} and Kampf, {Jeff W.} and Sanford, {Melanie S.}",

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AU - Kampf, Jeff W.

AU - Sanford, Melanie S.

PY - 2019/8/21

Y1 - 2019/8/21

N2 - The treatment of pyridine- and pyrazole-ligated NiII σ-aryl complexes with Selectfluor results in C(sp2)-F bond formation under mild conditions. With appropriate design of supporting ligands, diamagnetic NiIV σ-aryl fluoride intermediates can be detected spectroscopically and/or isolated during these transformations. These studies demonstrate for the first time that NiIV σ-aryl fluoride complexes participate in challenging C(sp2)-F bond-forming reductive elimination to yield aryl fluoride products.

AB - The treatment of pyridine- and pyrazole-ligated NiII σ-aryl complexes with Selectfluor results in C(sp2)-F bond formation under mild conditions. With appropriate design of supporting ligands, diamagnetic NiIV σ-aryl fluoride intermediates can be detected spectroscopically and/or isolated during these transformations. These studies demonstrate for the first time that NiIV σ-aryl fluoride complexes participate in challenging C(sp2)-F bond-forming reductive elimination to yield aryl fluoride products.

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IS - 33

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Aryl-Fluoride Bond-Forming Reductive Elimination from Nickel(IV) Centers

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