Ascorbyl-6-O-oleate: A Bioconjugate Antioxidant Lipid

Ilaria Perini; Moira Ambrosi; Damiano Tanini; Barry W. Ninham; Antonella Capperucci; Pierandrea Lo Nostro

doi:10.1002/slct.201903528

Ascorbyl-6-O-oleate: A Bioconjugate Antioxidant Lipid

Ilaria Perini, Moira Ambrosi, Damiano Tanini, Barry W. Ninham, Antonella Capperucci, Pierandrea Lo Nostro^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Ascorbyl-6-O-oleate (Asc-OL) was synthesized enzimatically and studied in the pure state and in aqueous dispersions. Small-angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), Fourier transformed infrared (FTIR) spectroscopy experiments and antioxidant tests were conducted in order to characterize the compound and to evaluate its reducing properties. Asc-OL is a bioconjugate molecule, in fact it combines the main physico-chemical features of the two parent molecules, i. e. the redox and acidic properties of Vitamin C and the fluid-like state of oleic acid. The appropriate tests were carried out to confirm the excellent radical scavenging activities of Asc-OL, that turned out to be a promising candidate for the stabilization, transport and protection against radical attack of valuable hydrophobic active ingredients used in food and pharmaceutical formulations.

Original language	English
Pages (from-to)	1938-1944
Number of pages	7
Journal	ChemistrySelect
Volume	5
Issue number	6
DOIs	https://doi.org/10.1002/slct.201903528
Publication status	Published - 14 Feb 2020

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title = "Ascorbyl-6-O-oleate: A Bioconjugate Antioxidant Lipid",

abstract = "Ascorbyl-6-O-oleate (Asc-OL) was synthesized enzimatically and studied in the pure state and in aqueous dispersions. Small-angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), Fourier transformed infrared (FTIR) spectroscopy experiments and antioxidant tests were conducted in order to characterize the compound and to evaluate its reducing properties. Asc-OL is a bioconjugate molecule, in fact it combines the main physico-chemical features of the two parent molecules, i. e. the redox and acidic properties of Vitamin C and the fluid-like state of oleic acid. The appropriate tests were carried out to confirm the excellent radical scavenging activities of Asc-OL, that turned out to be a promising candidate for the stabilization, transport and protection against radical attack of valuable hydrophobic active ingredients used in food and pharmaceutical formulations.",

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T2 - A Bioconjugate Antioxidant Lipid

AU - Perini, Ilaria

AU - Ambrosi, Moira

AU - Tanini, Damiano

AU - Ninham, Barry W.

AU - Capperucci, Antonella

AU - Nostro, Pierandrea Lo

PY - 2020/2/14

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AB - Ascorbyl-6-O-oleate (Asc-OL) was synthesized enzimatically and studied in the pure state and in aqueous dispersions. Small-angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), Fourier transformed infrared (FTIR) spectroscopy experiments and antioxidant tests were conducted in order to characterize the compound and to evaluate its reducing properties. Asc-OL is a bioconjugate molecule, in fact it combines the main physico-chemical features of the two parent molecules, i. e. the redox and acidic properties of Vitamin C and the fluid-like state of oleic acid. The appropriate tests were carried out to confirm the excellent radical scavenging activities of Asc-OL, that turned out to be a promising candidate for the stabilization, transport and protection against radical attack of valuable hydrophobic active ingredients used in food and pharmaceutical formulations.

KW - L-ascorbyl esters

KW - Vitamin C

KW - antioxidant

KW - micelle(s)

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Ascorbyl-6-O-oleate: A Bioconjugate Antioxidant Lipid

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