Assembling branched and macrocyclic peptides on proteins

Sven Ullrich; Santhanalaxmi Kumaresan; Marina G. Rahman; Bishvanwesha Panda; Richard Morewood; Christoph Nitsche

doi:10.1039/d4cc06442a

Assembling branched and macrocyclic peptides on proteins

Sven Ullrich
, Santhanalaxmi Kumaresan
, Marina G. Rahman
, Bishvanwesha Panda
, Richard Morewood
, Christoph Nitsche

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A two-step, biocompatible strategy enables site-specific generation of branched and macrocyclic peptide-protein conjugates. Solvent-exposed cysteines on proteins are modified by a small bifunctional reagent at near-physiological pH, followed by cyanopyridine-aminothiol click reactions to create branched or macrocyclic peptide architectures. This method offers design strategies for next-generation protein therapeutics.

Original language	English
Number of pages	4
Journal	Chemical Communications
Issue number	14
Early online date	Jan 2025
DOIs	https://doi.org/10.1039/d4cc06442a
Publication status	Published - 17 Jan 2025

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10.1039/d4cc06442a

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Assembling branched and macrocyclic peptides on proteins

Abstract

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