Assignment of the 13C and 15N NMR spectra of the antitumour antibiotic streptonigrin

Pia I. Anderberg; Ian J. Luck; Margaret M. Harding

doi:10.1002/mrc.997

Assignment of the ¹³C and ¹⁵N NMR spectra of the antitumour antibiotic streptonigrin

Pia I. Anderberg, Ian J. Luck, Margaret M. Harding^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

The assignments of the two pyridyl nitrogens and two amino nitrogens in the antitumour antibiotic streptonigrin, and all carbon resonances, were determined by ¹⁵N (HSQC, HMBC) and ¹³C (HSQC, HMBC) NMR techniques. These data provide useful probes for determination of the site(s) of metal complexation in the drug, which are important in the mechanism of antitumour activity.

Original language	English
Pages (from-to)	313-315
Number of pages	3
Journal	Magnetic Resonance in Chemistry
Volume	40
Issue number	4
DOIs	https://doi.org/10.1002/mrc.997
Publication status	Published - 1 Apr 2002
Externally published	Yes

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title = "Assignment of the 13C and 15N NMR spectra of the antitumour antibiotic streptonigrin",

abstract = "The assignments of the two pyridyl nitrogens and two amino nitrogens in the antitumour antibiotic streptonigrin, and all carbon resonances, were determined by 15N (HSQC, HMBC) and 13C (HSQC, HMBC) NMR techniques. These data provide useful probes for determination of the site(s) of metal complexation in the drug, which are important in the mechanism of antitumour activity.",

keywords = "2,2′-bipyridyl, Aminoquinone, C NMR, Metal complex, N NMR, NMR, Streptonigrin",

author = "Anderberg, {Pia I.} and Luck, {Ian J.} and Harding, {Margaret M.}",

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AU - Anderberg, Pia I.

AU - Luck, Ian J.

AU - Harding, Margaret M.

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Y1 - 2002/4/1

N2 - The assignments of the two pyridyl nitrogens and two amino nitrogens in the antitumour antibiotic streptonigrin, and all carbon resonances, were determined by 15N (HSQC, HMBC) and 13C (HSQC, HMBC) NMR techniques. These data provide useful probes for determination of the site(s) of metal complexation in the drug, which are important in the mechanism of antitumour activity.

AB - The assignments of the two pyridyl nitrogens and two amino nitrogens in the antitumour antibiotic streptonigrin, and all carbon resonances, were determined by 15N (HSQC, HMBC) and 13C (HSQC, HMBC) NMR techniques. These data provide useful probes for determination of the site(s) of metal complexation in the drug, which are important in the mechanism of antitumour activity.

KW - 2,2′-bipyridyl

KW - Aminoquinone

KW - C NMR

KW - Metal complex

KW - N NMR

KW - NMR

KW - Streptonigrin

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JO - Magnetic Resonance in Chemistry

JF - Magnetic Resonance in Chemistry

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ER -

Assignment of the ¹³C and ¹⁵N NMR spectra of the antitumour antibiotic streptonigrin

Abstract

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