Association of dopamine-β-hydroxylase and androgen receptor gene polymorphisms with Eysenck's P and other personality traits

R. Turakulov; Anthony F. Jorm; P. A. Jacomb; X. Tan; S. Easteal

doi:10.1016/j.paid.2003.08.011

Association of dopamine-β-hydroxylase and androgen receptor gene polymorphisms with Eysenck's P and other personality traits

R. Turakulov, Anthony F. Jorm^*, P. A. Jacomb, X. Tan, S. Easteal

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Biological theories of the personality trait of psychoticism (P) have proposed roles for low dopamine-β-hydoxylase and high testerosterone. It was therefore predicted that polymorphisms of the dopamine-β-hydroxylase and androgen receptor genes would be associated with P. Data were taken from a community survey of Australian adults who completed personality questionnaires and gave a DNA sample. 896 participants were genotyped for dopamine-β-hydroxylase C-1021T polymorphism, and 1676 and 1698 were genotyped for androgen receptor CAG and GGC repeat polymorphisms respectively. Males with short CAG alleles were found to have significantly higher P scores, but no other associations with P were found. Given the statistical power of the study, if there are associations with the polymorphisms investigated, they must be very small.

Original language	English
Pages (from-to)	191-202
Number of pages	12
Journal	Personality and Individual Differences
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/j.paid.2003.08.011
Publication status	Published - Jul 2004

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title = "Association of dopamine-β-hydroxylase and androgen receptor gene polymorphisms with Eysenck's P and other personality traits",

abstract = "Biological theories of the personality trait of psychoticism (P) have proposed roles for low dopamine-β-hydoxylase and high testerosterone. It was therefore predicted that polymorphisms of the dopamine-β-hydroxylase and androgen receptor genes would be associated with P. Data were taken from a community survey of Australian adults who completed personality questionnaires and gave a DNA sample. 896 participants were genotyped for dopamine-β-hydroxylase C-1021T polymorphism, and 1676 and 1698 were genotyped for androgen receptor CAG and GGC repeat polymorphisms respectively. Males with short CAG alleles were found to have significantly higher P scores, but no other associations with P were found. Given the statistical power of the study, if there are associations with the polymorphisms investigated, they must be very small.",

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AU - Turakulov, R.

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AU - Jacomb, P. A.

AU - Tan, X.

AU - Easteal, S.

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AB - Biological theories of the personality trait of psychoticism (P) have proposed roles for low dopamine-β-hydoxylase and high testerosterone. It was therefore predicted that polymorphisms of the dopamine-β-hydroxylase and androgen receptor genes would be associated with P. Data were taken from a community survey of Australian adults who completed personality questionnaires and gave a DNA sample. 896 participants were genotyped for dopamine-β-hydroxylase C-1021T polymorphism, and 1676 and 1698 were genotyped for androgen receptor CAG and GGC repeat polymorphisms respectively. Males with short CAG alleles were found to have significantly higher P scores, but no other associations with P were found. Given the statistical power of the study, if there are associations with the polymorphisms investigated, they must be very small.

KW - Androgen receptor

KW - Dopamine-β-hydroxylase

KW - Extraversion

KW - Genetics

KW - Neuroticism

KW - Psychoticism

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JO - Personality and Individual Differences

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Association of dopamine-β-hydroxylase and androgen receptor gene polymorphisms with Eysenck's P and other personality traits

Abstract

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