Association of Suboptimal Antiretroviral Therapy Adherence with Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study

Jose R. Castillo-Mancilla; Andrew N. Phillips; James D. Neaton; Jacqueline Neuhaus; Simon Collins; Sharon Mannheimer; Sarah Pett; Veronique Touzeau-Römer; Mark N. Polizzotto; Jens D. Lundgren; Edward M. Gardner

doi:10.1093/ofid/ofx275

Association of Suboptimal Antiretroviral Therapy Adherence with Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study

Jose R. Castillo-Mancilla^*, Andrew N. Phillips, James D. Neaton, Jacqueline Neuhaus, Simon Collins, Sharon Mannheimer, Sarah Pett, Veronique Touzeau-Römer, Mark N. Polizzotto, Jens D. Lundgren, Edward M. Gardner

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Suboptimal (ie, <100%) antiretroviral therapy (ART) adherence has been associated with heightened inflammation in cohort studies, even among people with virologic suppression. We aimed to evaluate this association among participants in the Strategies for Management of Antiretroviral Therapy (SMART) study who had virologic suppression (HIV-1 VL < 200 copies/mL) at enrollment. Based on self-reported adherence (7-day recall), plasma concentrations of interleukin 6 and D-dimer were 9% (95% confidence interval [CI], 1%-18%; P = .02) and 11% (95% CI, 1%-22%; P = .03) higher in participants who reported suboptimal vs 100% adherence, respectively. These findings confirm previous observations and support the hypothesis that suboptimal ART adherence, even in the context of virologic suppression, may have significant biological consequences. ClinicalTrials.gov number NCT00027352.

Original language	English
Article number	ofx275
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	1
DOIs	https://doi.org/10.1093/ofid/ofx275
Publication status	Published - 1 Jan 2018
Externally published	Yes

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Castillo-Mancilla, J. R., Phillips, A. N., Neaton, J. D., Neuhaus, J., Collins, S., Mannheimer, S., Pett, S., Touzeau-Römer, V., Polizzotto, M. N., Lundgren, J. D., & Gardner, E. M. (2018). Association of Suboptimal Antiretroviral Therapy Adherence with Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study. Open Forum Infectious Diseases, 5(1), Article ofx275. https://doi.org/10.1093/ofid/ofx275

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title = "Association of Suboptimal Antiretroviral Therapy Adherence with Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study",

abstract = "Suboptimal (ie, <100%) antiretroviral therapy (ART) adherence has been associated with heightened inflammation in cohort studies, even among people with virologic suppression. We aimed to evaluate this association among participants in the Strategies for Management of Antiretroviral Therapy (SMART) study who had virologic suppression (HIV-1 VL < 200 copies/mL) at enrollment. Based on self-reported adherence (7-day recall), plasma concentrations of interleukin 6 and D-dimer were 9% (95% confidence interval [CI], 1%-18%; P = .02) and 11% (95% CI, 1%-22%; P = .03) higher in participants who reported suboptimal vs 100% adherence, respectively. These findings confirm previous observations and support the hypothesis that suboptimal ART adherence, even in the context of virologic suppression, may have significant biological consequences. ClinicalTrials.gov number NCT00027352.",

keywords = "Adherence, SMART study., antiretroviral therapy, inflammation",

author = "Castillo-Mancilla, {Jose R.} and Phillips, {Andrew N.} and Neaton, {James D.} and Jacqueline Neuhaus and Simon Collins and Sharon Mannheimer and Sarah Pett and Veronique Touzeau-R{\"o}mer and Polizzotto, {Mark N.} and Lundgren, {Jens D.} and Gardner, {Edward M.}",

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Castillo-Mancilla, JR, Phillips, AN, Neaton, JD, Neuhaus, J, Collins, S, Mannheimer, S, Pett, S, Touzeau-Römer, V, Polizzotto, MN, Lundgren, JD & Gardner, EM 2018, 'Association of Suboptimal Antiretroviral Therapy Adherence with Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study', Open Forum Infectious Diseases, vol. 5, no. 1, ofx275. https://doi.org/10.1093/ofid/ofx275

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AU - Castillo-Mancilla, Jose R.

AU - Phillips, Andrew N.

AU - Neaton, James D.

AU - Neuhaus, Jacqueline

AU - Collins, Simon

AU - Mannheimer, Sharon

AU - Pett, Sarah

AU - Touzeau-Römer, Veronique

AU - Polizzotto, Mark N.

AU - Lundgren, Jens D.

AU - Gardner, Edward M.

PY - 2018/1/1

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N2 - Suboptimal (ie, <100%) antiretroviral therapy (ART) adherence has been associated with heightened inflammation in cohort studies, even among people with virologic suppression. We aimed to evaluate this association among participants in the Strategies for Management of Antiretroviral Therapy (SMART) study who had virologic suppression (HIV-1 VL < 200 copies/mL) at enrollment. Based on self-reported adherence (7-day recall), plasma concentrations of interleukin 6 and D-dimer were 9% (95% confidence interval [CI], 1%-18%; P = .02) and 11% (95% CI, 1%-22%; P = .03) higher in participants who reported suboptimal vs 100% adherence, respectively. These findings confirm previous observations and support the hypothesis that suboptimal ART adherence, even in the context of virologic suppression, may have significant biological consequences. ClinicalTrials.gov number NCT00027352.

AB - Suboptimal (ie, <100%) antiretroviral therapy (ART) adherence has been associated with heightened inflammation in cohort studies, even among people with virologic suppression. We aimed to evaluate this association among participants in the Strategies for Management of Antiretroviral Therapy (SMART) study who had virologic suppression (HIV-1 VL < 200 copies/mL) at enrollment. Based on self-reported adherence (7-day recall), plasma concentrations of interleukin 6 and D-dimer were 9% (95% confidence interval [CI], 1%-18%; P = .02) and 11% (95% CI, 1%-22%; P = .03) higher in participants who reported suboptimal vs 100% adherence, respectively. These findings confirm previous observations and support the hypothesis that suboptimal ART adherence, even in the context of virologic suppression, may have significant biological consequences. ClinicalTrials.gov number NCT00027352.

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Association of Suboptimal Antiretroviral Therapy Adherence with Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study

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