Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men

D. J. Lehmann; H. T. Butler; D. R. Warden; M. Combrinck; E. King; J. A.R. Nicoll; M. M. Budge; C. A. De Jager; E. Hogervorst; M. M. Esiri; J. Ragoussis; A. D. Smith

doi:10.1016/S0304-3940(03)00069-7

Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men

D. J. Lehmann^*, H. T. Butler, D. R. Warden, M. Combrinck, E. King, J. A.R. Nicoll, M. M. Budge, C. A. De Jager, E. Hogervorst, M. M. Esiri, J. Ragoussis, A. D. Smith

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

We examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (≤20 CAG repeats) were associated with AD (adjusted odds ratio=2.5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (<65 years). We conclude that this AR polymorphism is of potential relevance to the risk of AD in men.

Original language	English
Pages (from-to)	87-90
Number of pages	4
Journal	Neuroscience Letters
Volume	340
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(03)00069-7
Publication status	Published - 10 Apr 2003
Externally published	Yes

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10.1016/S0304-3940(03)00069-7

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title = "Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men",

abstract = "We examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (≤20 CAG repeats) were associated with AD (adjusted odds ratio=2.5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (<65 years). We conclude that this AR polymorphism is of potential relevance to the risk of AD in men.",

keywords = "Apolipoprotein E ε4, Butyrylcholinesterase K variant, Estrogen, Gender, Neuroprotection, Sex steroids, Testosterone, X chromosome",

author = "Lehmann, {D. J.} and Butler, {H. T.} and Warden, {D. R.} and M. Combrinck and E. King and Nicoll, {J. A.R.} and Budge, {M. M.} and {De Jager}, {C. A.} and E. Hogervorst and Esiri, {M. M.} and J. Ragoussis and Smith, {A. D.}",

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T1 - Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men

AU - Lehmann, D. J.

AU - Butler, H. T.

AU - Warden, D. R.

AU - Combrinck, M.

AU - King, E.

AU - Nicoll, J. A.R.

AU - Budge, M. M.

AU - De Jager, C. A.

AU - Hogervorst, E.

AU - Esiri, M. M.

AU - Ragoussis, J.

AU - Smith, A. D.

PY - 2003/4/10

Y1 - 2003/4/10

N2 - We examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (≤20 CAG repeats) were associated with AD (adjusted odds ratio=2.5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (<65 years). We conclude that this AR polymorphism is of potential relevance to the risk of AD in men.

AB - We examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (≤20 CAG repeats) were associated with AD (adjusted odds ratio=2.5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (<65 years). We conclude that this AR polymorphism is of potential relevance to the risk of AD in men.

KW - Apolipoprotein E ε4

KW - Butyrylcholinesterase K variant

KW - Estrogen

KW - Gender

KW - Neuroprotection

KW - Sex steroids

KW - Testosterone

KW - X chromosome

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DO - 10.1016/S0304-3940(03)00069-7

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VL - 340

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EP - 90

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Association of the androgen receptor CAG repeat polymorphism with Alzheimer's disease in men

Abstract

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