Abstract
We examined the CAG repeat polymorphism in exon 1 of the androgen receptor (AR) in an Oxford cohort of 150 cases (101 men) of definite or probable Alzheimer's disease (AD) and 190 elderly controls (140 men). We found that short alleles (≤20 CAG repeats) were associated with AD (adjusted odds ratio=2.5, 95% confidence intervals: 1.2-5.0) in men, but not in women. This association appeared stronger in early-onset AD (<65 years). We conclude that this AR polymorphism is of potential relevance to the risk of AD in men.
Original language | English |
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Pages (from-to) | 87-90 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 340 |
Issue number | 2 |
DOIs | |
Publication status | Published - 10 Apr 2003 |
Externally published | Yes |