Association of TNF-α-857C with inflammatory bowel disease in the Australian population

N. J. O'Callaghan; K. E. Adams; D. A. Van Heel; Juleen A. Cavanaugh

doi:10.1080/00365520310002508

Association of TNF-α-857C with inflammatory bowel disease in the Australian population

N. J. O'Callaghan, K. E. Adams, D. A. Van Heel, Juleen A. Cavanaugh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Background: It is now well established that susceptibility to inflammatory bowel disease is in part genetic, with one localization on chromosome 6 (IBD3) having been replicated in a number of populations. A candidate in that region, TNF-α, contains polymorphisms in the promoter region that appear to be associated with disease. Methods: More than 600 individuals from 170 multiplex IBD families were genotyped for four polymorphisms in the TNF-α gene and analysed for association. Results and Conclusion: A strong association was observed between transmission of the -857 C allele and disease. This effect was strongest in those families in which the NOD2 risk alleles are also segregating, supporting the existence of an interaction between IBD3 and IBD1 on chromosome 16.

Original language	English
Pages (from-to)	533-534
Number of pages	2
Journal	Scandinavian Journal of Gastroenterology
Volume	38
Issue number	5
DOIs	https://doi.org/10.1080/00365520310002508
Publication status	Published - 1 May 2003

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title = "Association of TNF-α-857C with inflammatory bowel disease in the Australian population",

abstract = "Background: It is now well established that susceptibility to inflammatory bowel disease is in part genetic, with one localization on chromosome 6 (IBD3) having been replicated in a number of populations. A candidate in that region, TNF-α, contains polymorphisms in the promoter region that appear to be associated with disease. Methods: More than 600 individuals from 170 multiplex IBD families were genotyped for four polymorphisms in the TNF-α gene and analysed for association. Results and Conclusion: A strong association was observed between transmission of the -857 C allele and disease. This effect was strongest in those families in which the NOD2 risk alleles are also segregating, supporting the existence of an interaction between IBD3 and IBD1 on chromosome 16.",

keywords = "Inflammatory bowel disease, Tumour necrosis factor alpha",

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AU - Van Heel, D. A.

AU - Cavanaugh, Juleen A.

PY - 2003/5/1

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N2 - Background: It is now well established that susceptibility to inflammatory bowel disease is in part genetic, with one localization on chromosome 6 (IBD3) having been replicated in a number of populations. A candidate in that region, TNF-α, contains polymorphisms in the promoter region that appear to be associated with disease. Methods: More than 600 individuals from 170 multiplex IBD families were genotyped for four polymorphisms in the TNF-α gene and analysed for association. Results and Conclusion: A strong association was observed between transmission of the -857 C allele and disease. This effect was strongest in those families in which the NOD2 risk alleles are also segregating, supporting the existence of an interaction between IBD3 and IBD1 on chromosome 16.

AB - Background: It is now well established that susceptibility to inflammatory bowel disease is in part genetic, with one localization on chromosome 6 (IBD3) having been replicated in a number of populations. A candidate in that region, TNF-α, contains polymorphisms in the promoter region that appear to be associated with disease. Methods: More than 600 individuals from 170 multiplex IBD families were genotyped for four polymorphisms in the TNF-α gene and analysed for association. Results and Conclusion: A strong association was observed between transmission of the -857 C allele and disease. This effect was strongest in those families in which the NOD2 risk alleles are also segregating, supporting the existence of an interaction between IBD3 and IBD1 on chromosome 16.

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Association of TNF-α-857C with inflammatory bowel disease in the Australian population

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