TY - JOUR
T1 - Asymmetric aldol reactions using boron enolates
T2 - Applications to polyketide synthesis
AU - Paterson, Ian
AU - Doughty, Victoria A.
AU - Florence, Gordon
AU - Gerlach, Kai
AU - McLeod, Malcolm D.
AU - Scott, Jeremy P.
AU - Trieselmann, Thomas
PY - 2001
Y1 - 2001
N2 - The chiral boron enolates 7-14 add to aldehydes with high levels of stereocontrol in a predictable sense. These enolates are designed specifically for the aldol-based construction of the highly oxygenated and stereochemically challenging structures found in polyketide natural products, as illustrated here by their application to the total synthesis of concanamycin F and discodermolide.
AB - The chiral boron enolates 7-14 add to aldehydes with high levels of stereocontrol in a predictable sense. These enolates are designed specifically for the aldol-based construction of the highly oxygenated and stereochemically challenging structures found in polyketide natural products, as illustrated here by their application to the total synthesis of concanamycin F and discodermolide.
UR - http://www.scopus.com/inward/record.url?scp=0042850737&partnerID=8YFLogxK
U2 - 10.1021/bk-2001-0783.ch014
DO - 10.1021/bk-2001-0783.ch014
M3 - Article
AN - SCOPUS:0042850737
SN - 0097-6156
VL - 783
SP - 195
EP - 206
JO - ACS Symposium Series
JF - ACS Symposium Series
ER -