Asymmetric partitioning of anions in lysozyme dispersions

Pierandrea Lo Nostro; Niccolò Peruzzi; Mirko Severi; Barry W. Ninham; Piero Baglioni

doi:10.1021/ja101603n

Asymmetric partitioning of anions in lysozyme dispersions

Pierandrea Lo Nostro^*, Niccolò Peruzzi, Mirko Severi, Barry W. Ninham, Piero Baglioni

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

An aqueous dispersion of lysozyme and sodium dodecyl sulfate phase separates below the cloud point. Two liquid phases are formed. At pH < pI electrolytes change the cloud point temperatures (T_c). These follow an inverse Hofmeister series. Anions partition asymmetrically between the two phases. At fixed cation, the partitioning depends on the specific anion. In a system of finite volume, a concentrated dispersion of a protein is able to act as a chemical "sponge". No active pump is necessary to maintain concentration differences between concentrated and dilute dispersions.

Original language	English
Pages (from-to)	6571-6577
Number of pages	7
Journal	Journal of the American Chemical Society
Volume	132
Issue number	18
DOIs	https://doi.org/10.1021/ja101603n
Publication status	Published - 12 May 2010

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AU - Lo Nostro, Pierandrea

AU - Peruzzi, Niccolò

AU - Severi, Mirko

AU - Ninham, Barry W.

AU - Baglioni, Piero

PY - 2010/5/12

Y1 - 2010/5/12

N2 - An aqueous dispersion of lysozyme and sodium dodecyl sulfate phase separates below the cloud point. Two liquid phases are formed. At pH < pI electrolytes change the cloud point temperatures (Tc). These follow an inverse Hofmeister series. Anions partition asymmetrically between the two phases. At fixed cation, the partitioning depends on the specific anion. In a system of finite volume, a concentrated dispersion of a protein is able to act as a chemical "sponge". No active pump is necessary to maintain concentration differences between concentrated and dilute dispersions.

AB - An aqueous dispersion of lysozyme and sodium dodecyl sulfate phase separates below the cloud point. Two liquid phases are formed. At pH < pI electrolytes change the cloud point temperatures (Tc). These follow an inverse Hofmeister series. Anions partition asymmetrically between the two phases. At fixed cation, the partitioning depends on the specific anion. In a system of finite volume, a concentrated dispersion of a protein is able to act as a chemical "sponge". No active pump is necessary to maintain concentration differences between concentrated and dilute dispersions.

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Asymmetric partitioning of anions in lysozyme dispersions

Abstract

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