TY - JOUR
T1 - ATRX and sex differentiation
AU - Tang, Paisu
AU - Park, Daniel J.
AU - Graves, Jennifer A.Marshall
AU - Harley, Vincent R.
PY - 2004/9
Y1 - 2004/9
N2 - Most interest in the gene encoding the α-thalassemia, mental retardation, X-linked protein (ATRX) has traditionally been focused on its role in brain development and globin regulation. However, mutations in the ATRX gene also cause varying degrees of gonadal and urogenital abnormalities. These range from small testes to ambiguous external genitalia in XY individuals. ATRX is of great interest because this very large protein is one of the least understood proteins involved in mammalian sexual development. Although the biochemical role of ATRX remains unknown, recent and emerging evidence implicates ATRX in chromatin remodeling. We review what is known about ATRX as a chromatin remodeling protein, and its role in mammalian sex differentiation.
AB - Most interest in the gene encoding the α-thalassemia, mental retardation, X-linked protein (ATRX) has traditionally been focused on its role in brain development and globin regulation. However, mutations in the ATRX gene also cause varying degrees of gonadal and urogenital abnormalities. These range from small testes to ambiguous external genitalia in XY individuals. ATRX is of great interest because this very large protein is one of the least understood proteins involved in mammalian sexual development. Although the biochemical role of ATRX remains unknown, recent and emerging evidence implicates ATRX in chromatin remodeling. We review what is known about ATRX as a chromatin remodeling protein, and its role in mammalian sex differentiation.
UR - http://www.scopus.com/inward/record.url?scp=4444253540&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2004.07.006
DO - 10.1016/j.tem.2004.07.006
M3 - Review article
SN - 1043-2760
VL - 15
SP - 339
EP - 344
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 7
ER -