Autoimmune diabetes in the NOD nouse: An essential role of Fas-FasL signaling in β cell apoptosis

Diego G. Silva; Luis Socha; Brett Charlton; William Cowden; Nikolai Petrovsky

doi:10.1196/annals.1288.018

Autoimmune diabetes in the NOD nouse: An essential role of Fas-FasL signaling in β cell apoptosis

Diego G. Silva, Luis Socha, Brett Charlton, William Cowden, Nikolai Petrovsky^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Despite evidence that both Fas and FasL can be expressed in pancreatic islets, there has been considerable controversy regarding the potential role of Fas signaling in autoimmune β cell death. Using the HIPFasL model, we have been able to demonstrate that, in the presence of an inflammatory infiltrate, FasL-expressing β cells are exquisitely sensitive to Fas-mediated apoptosis and that this can be blocked by preventing FasL-Fas interaction. This points to a highly important role of Fas-FasL interaction in autoimmune β cell death.

Original language	English
Pages (from-to)	161-165
Number of pages	5
Journal	Annals of the New York Academy of Sciences
Volume	1005
DOIs	https://doi.org/10.1196/annals.1288.018
Publication status	Published - 2003

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title = "Autoimmune diabetes in the NOD nouse: An essential role of Fas-FasL signaling in β cell apoptosis",

abstract = "Despite evidence that both Fas and FasL can be expressed in pancreatic islets, there has been considerable controversy regarding the potential role of Fas signaling in autoimmune β cell death. Using the HIPFasL model, we have been able to demonstrate that, in the presence of an inflammatory infiltrate, FasL-expressing β cells are exquisitely sensitive to Fas-mediated apoptosis and that this can be blocked by preventing FasL-Fas interaction. This points to a highly important role of Fas-FasL interaction in autoimmune β cell death.",

keywords = "Apoptosis, Autoimmunity, Fas ligand, NOD, Type 1 diabetes",

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T1 - Autoimmune diabetes in the NOD nouse

T2 - An essential role of Fas-FasL signaling in β cell apoptosis

AU - Silva, Diego G.

AU - Socha, Luis

AU - Charlton, Brett

AU - Cowden, William

AU - Petrovsky, Nikolai

PY - 2003

Y1 - 2003

N2 - Despite evidence that both Fas and FasL can be expressed in pancreatic islets, there has been considerable controversy regarding the potential role of Fas signaling in autoimmune β cell death. Using the HIPFasL model, we have been able to demonstrate that, in the presence of an inflammatory infiltrate, FasL-expressing β cells are exquisitely sensitive to Fas-mediated apoptosis and that this can be blocked by preventing FasL-Fas interaction. This points to a highly important role of Fas-FasL interaction in autoimmune β cell death.

AB - Despite evidence that both Fas and FasL can be expressed in pancreatic islets, there has been considerable controversy regarding the potential role of Fas signaling in autoimmune β cell death. Using the HIPFasL model, we have been able to demonstrate that, in the presence of an inflammatory infiltrate, FasL-expressing β cells are exquisitely sensitive to Fas-mediated apoptosis and that this can be blocked by preventing FasL-Fas interaction. This points to a highly important role of Fas-FasL interaction in autoimmune β cell death.

KW - Apoptosis

KW - Autoimmunity

KW - Fas ligand

KW - NOD

KW - Type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=1942475188&partnerID=8YFLogxK

U2 - 10.1196/annals.1288.018

DO - 10.1196/annals.1288.018

M3 - Article

SN - 0077-8923

VL - 1005

SP - 161

EP - 165

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Autoimmune diabetes in the NOD nouse: An essential role of Fas-FasL signaling in β cell apoptosis

Abstract

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