Automatic sound speed selection in photoacoustic image reconstruction using an autofocus approach

Bradley E. Treeby*, Trond K. Varslot, Edward Z. Zhang, Jan G. Laufer, Paul C. Beard

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    97 Citations (Scopus)

    Abstract

    The reconstruction of images in photoacoustic tomography is reliant on specifying the speed of sound within the propagation medium. However, for in vivo imaging, this value is not normally accurately known. Here, an autofocus approach for automatically selecting the sound speed is proposed. This is based on maximizing the sharpness of the reconstructed image as quantified by a focus function. Several focus functions are investigated, and their performance is discussed. The method is demonstrated using phantom measurements made in a medium with a known sound speed and in vivo measurements of the vasculature in the flank of an adult mouse.

    Original languageEnglish
    Article number090501
    JournalJournal of Biomedical Optics
    Volume16
    Issue number9
    DOIs
    Publication statusPublished - Sept 2011

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