Axe: Rapid, competitive sequence read demultiplexing using a trie

Kevin D. Murray; Justin O. Borevitz

doi:10.1093/bioinformatics/bty432

Axe: Rapid, competitive sequence read demultiplexing using a trie

Kevin D. Murray^*, Justin O. Borevitz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Summary We describe a rapid algorithm for demultiplexing DNA sequence reads with in-read indices. Axe selects the optimal index present in a sequence read, even in the presence of sequencing errors. The algorithm is able to handle combinatorial indexing, indices of differing length and several mismatches per index sequence. Availability and implementation Axe is implemented in C, and is used as a command-line program on Unix-like systems. Axe is available online at https://github.com/kdmurray91/axe, and is available in Debian/Ubuntu distributions of GNU/Linux as the package axe-demultiplexer. Supplementary informationSupplementary dataare available at Bioinformatics online.

Original language	English
Pages (from-to)	3924-3925
Number of pages	2
Journal	Bioinformatics
Volume	34
Issue number	22
DOIs	https://doi.org/10.1093/bioinformatics/bty432
Publication status	Published - 15 Nov 2018

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abstract = "Summary We describe a rapid algorithm for demultiplexing DNA sequence reads with in-read indices. Axe selects the optimal index present in a sequence read, even in the presence of sequencing errors. The algorithm is able to handle combinatorial indexing, indices of differing length and several mismatches per index sequence. Availability and implementation Axe is implemented in C, and is used as a command-line program on Unix-like systems. Axe is available online at https://github.com/kdmurray91/axe, and is available in Debian/Ubuntu distributions of GNU/Linux as the package axe-demultiplexer. Supplementary informationSupplementary dataare available at Bioinformatics online.",

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Axe: Rapid, competitive sequence read demultiplexing using a trie

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