Bacterial causes of empyema in children, Australia, 2007-2009

Roxanne E. Strachan; Anita Cornelius; Gwendolyn L. Gilbert; Tanya Gulliver; Andrew Martin; Tim McDonald; Gillian M. Nixon; Rob Roseby; Sarath Ranganathan; Hiran Selvadurai; Greg Smith; Manuel Soto-Martinez; Sadasivam Suresh; Laurel Teoh; Kiran Thapa; Claire E. Wainwright; Adam Jaffé

doi:10.3201/eid1710.101825

Bacterial causes of empyema in children, Australia, 2007-2009

Roxanne E. Strachan, Anita Cornelius, Gwendolyn L. Gilbert, Tanya Gulliver, Andrew Martin, Tim McDonald, Gillian M. Nixon, Rob Roseby, Sarath Ranganathan, Hiran Selvadurai, Greg Smith, Manuel Soto-Martinez, Sadasivam Suresh, Laurel Teoh, Kiran Thapa, Claire E. Wainwright, Adam Jaffé^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

An increase in the incidence of empyema worldwide could be related to invasive pneumococcal disease caused by emergent nonvaccine replacement serotypes. To determine bacterial pathogens and pneumococcal serotypes that cause empyema in children in Australia, we conducted a 2-year study of 174 children with empyema. Blood and pleural fluid samples were cultured, and pleural fluid was tested by PCR. Thirty-two (21.0%) of 152 blood and 53 (33.1%) of 160 pleural fluid cultures were positive for bacteria; Streptococcus pneumoniae was the most common organism identified. PCR identified S. pneumoniae in 74 (51.7%) and other bacteria in 19 (13.1%) of 145 pleural fluid specimens. Of 53 samples in which S. pneumoniae serotypes were identified, 2 (3.8%) had vaccine-related serotypes and 51 (96.2%) had nonvaccine serotypes; 19A (n = 20; 36.4%), 3 (n = 18; 32.7%), and 1 (n = 8; 14.5%) were the most common. High proportions of nonvaccine serotypes suggest the need to broaden vaccine coverage.

Original language	English
Pages (from-to)	1839-1845
Number of pages	7
Journal	Emerging Infectious Diseases
Volume	17
Issue number	10
DOIs	https://doi.org/10.3201/eid1710.101825
Publication status	Published - Oct 2011
Externally published	Yes

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Strachan, R. E., Cornelius, A., Gilbert, G. L., Gulliver, T., Martin, A., McDonald, T., Nixon, G. M., Roseby, R., Ranganathan, S., Selvadurai, H., Smith, G., Soto-Martinez, M., Suresh, S., Teoh, L., Thapa, K., Wainwright, C. E., & Jaffé, A. (2011). Bacterial causes of empyema in children, Australia, 2007-2009. Emerging Infectious Diseases, 17(10), 1839-1845. https://doi.org/10.3201/eid1710.101825

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title = "Bacterial causes of empyema in children, Australia, 2007-2009",

abstract = "An increase in the incidence of empyema worldwide could be related to invasive pneumococcal disease caused by emergent nonvaccine replacement serotypes. To determine bacterial pathogens and pneumococcal serotypes that cause empyema in children in Australia, we conducted a 2-year study of 174 children with empyema. Blood and pleural fluid samples were cultured, and pleural fluid was tested by PCR. Thirty-two (21.0%) of 152 blood and 53 (33.1%) of 160 pleural fluid cultures were positive for bacteria; Streptococcus pneumoniae was the most common organism identified. PCR identified S. pneumoniae in 74 (51.7%) and other bacteria in 19 (13.1%) of 145 pleural fluid specimens. Of 53 samples in which S. pneumoniae serotypes were identified, 2 (3.8%) had vaccine-related serotypes and 51 (96.2%) had nonvaccine serotypes; 19A (n = 20; 36.4%), 3 (n = 18; 32.7%), and 1 (n = 8; 14.5%) were the most common. High proportions of nonvaccine serotypes suggest the need to broaden vaccine coverage.",

author = "Strachan, {Roxanne E.} and Anita Cornelius and Gilbert, {Gwendolyn L.} and Tanya Gulliver and Andrew Martin and Tim McDonald and Nixon, {Gillian M.} and Rob Roseby and Sarath Ranganathan and Hiran Selvadurai and Greg Smith and Manuel Soto-Martinez and Sadasivam Suresh and Laurel Teoh and Kiran Thapa and Wainwright, {Claire E.} and Adam Jaff{\'e}",

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Strachan, RE, Cornelius, A, Gilbert, GL, Gulliver, T, Martin, A, McDonald, T, Nixon, GM, Roseby, R, Ranganathan, S, Selvadurai, H, Smith, G, Soto-Martinez, M, Suresh, S, Teoh, L, Thapa, K, Wainwright, CE & Jaffé, A 2011, 'Bacterial causes of empyema in children, Australia, 2007-2009', Emerging Infectious Diseases, vol. 17, no. 10, pp. 1839-1845. https://doi.org/10.3201/eid1710.101825

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AU - Soto-Martinez, Manuel

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Bacterial causes of empyema in children, Australia, 2007-2009

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