TY - JOUR
T1 - Beta-actin variant is necessary for Enterovirus 71 replication
AU - Lui, Yan Long Edmund
AU - Lin, Zhiyang
AU - Lee, Jia Jun
AU - Chow, Vincent Tak Kwong
AU - Poh, Chit Laa
AU - Tan, Eng Lee
PY - 2013/4/19
Y1 - 2013/4/19
N2 - Enterovirus 71 (EV71) is one of the main etiological agents of the Hand, Foot and Mouth Disease (HFMD) and has been known to cause fatal neurological complications such as herpangina, aseptic meningitis, poliomyelitis-like paralysis and encephalitis. EV71 is endemic in the Asia-Pacific region and causes occasional epidemics. In order to better understand EV71 infection, we compared the proteome between EV71-susceptible and EV71-resistant human Rhabdomyosarcoma (RD) cell line. We found significant differences in the β-actin variants between the EV71-susceptible RD cells and EV71-resistant RD cells, suggesting that β-actin, in association with other proteins such as annexin 2 is required in vesicular transport of EV71. This finding further support our previous study that actin potentially plays a role in pathogenesis and the establishment of the disease in HFMD.
AB - Enterovirus 71 (EV71) is one of the main etiological agents of the Hand, Foot and Mouth Disease (HFMD) and has been known to cause fatal neurological complications such as herpangina, aseptic meningitis, poliomyelitis-like paralysis and encephalitis. EV71 is endemic in the Asia-Pacific region and causes occasional epidemics. In order to better understand EV71 infection, we compared the proteome between EV71-susceptible and EV71-resistant human Rhabdomyosarcoma (RD) cell line. We found significant differences in the β-actin variants between the EV71-susceptible RD cells and EV71-resistant RD cells, suggesting that β-actin, in association with other proteins such as annexin 2 is required in vesicular transport of EV71. This finding further support our previous study that actin potentially plays a role in pathogenesis and the establishment of the disease in HFMD.
KW - Annexin 2
KW - Beta-actin
KW - Hand, Foot and Mouth Disease
KW - Potentially fatal Enterovirus 71
KW - Rhabdomyosarcoma cell
UR - http://www.scopus.com/inward/record.url?scp=84876474351&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2013.03.044
DO - 10.1016/j.bbrc.2013.03.044
M3 - Article
SN - 0006-291X
VL - 433
SP - 607
EP - 610
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -