Beyond the discovery void: New targets for antibacterial compounds

Claire E. Broughton; Hugo A. Van Den Berg; Alan M. Wemyss; David I. Roper; Alison Rodger

doi:10.3184/003685016X14616130512308

Beyond the discovery void: New targets for antibacterial compounds

Claire E. Broughton
, Hugo A. Van Den Berg
, Alan M. Wemyss
, David I. Roper
, Alison Rodger

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Antibiotics save many lives, but their efficacy is under threat: overprescription, populationgrowth, and global travel all contribute to the rapid origination and spread of resistantstrains. Exacerbating this threat is the fact that no new major classes of antibioticshave been discovered in the last 30 years: this is the “discovery void.” We discuss thetraditional molecular targets of antibiotics as well as putative novel targets.

Original language	English
Pages (from-to)	153-182
Number of pages	30
Journal	Science Progress
Volume	99
Issue number	2
DOIs	https://doi.org/10.3184/003685016X14616130512308
Publication status	Published - Jun 2016
Externally published	Yes

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10.3184/003685016X14616130512308

Cite this

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title = "Beyond the discovery void: New targets for antibacterial compounds",

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keywords = "Antibiotics, Bacterial resistances to antibiotics, Cell division, Cellwall, Discovery void, MRSA",

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AU - Rodger, Alison

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AB - Antibiotics save many lives, but their efficacy is under threat: overprescription, populationgrowth, and global travel all contribute to the rapid origination and spread of resistantstrains. Exacerbating this threat is the fact that no new major classes of antibioticshave been discovered in the last 30 years: this is the “discovery void.” We discuss thetraditional molecular targets of antibiotics as well as putative novel targets.

KW - Antibiotics

KW - Bacterial resistances to antibiotics

KW - Cell division

KW - Cellwall

KW - Discovery void

KW - MRSA

UR - https://www.scopus.com/pages/publications/84975065694

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Beyond the discovery void: New targets for antibacterial compounds

Abstract

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