Bioinspired surface modification of orthopedic implants for bone tissue engineering

Chao Hu; D. Ashok; David R. Nisbet; Vini Gautam

doi:10.1016/j.biomaterials.2019.119366

Bioinspired surface modification of orthopedic implants for bone tissue engineering

Chao Hu, D. Ashok, David R. Nisbet, Vini Gautam^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

247 Citations (Scopus)

Abstract

Biomedical implants have been widely used in various orthopedic treatments, including total hip arthroplasty, joint arthrodesis, fracture fixation, non-union, dental repair, etc. The modern research and development of orthopedic implants have gradually shifted from traditional mechanical support to a bioactive graft in order to endow them with better osteoinduction and osteoconduction. Inspired by structural and mechanical properties of natural bone, this review provides a panorama of current biological surface modifications for facilitating the interaction between medical implants and bone tissue and gives a future outlook for fabricating the next-generation multifunctional and smart implants by systematically biomimicking the physiological processes involved in formation and functioning of bones.

Original language	English
Article number	119366
Journal	Biomaterials
Volume	219
DOIs	https://doi.org/10.1016/j.biomaterials.2019.119366
Publication status	Published - Oct 2019

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title = "Bioinspired surface modification of orthopedic implants for bone tissue engineering",

abstract = "Biomedical implants have been widely used in various orthopedic treatments, including total hip arthroplasty, joint arthrodesis, fracture fixation, non-union, dental repair, etc. The modern research and development of orthopedic implants have gradually shifted from traditional mechanical support to a bioactive graft in order to endow them with better osteoinduction and osteoconduction. Inspired by structural and mechanical properties of natural bone, this review provides a panorama of current biological surface modifications for facilitating the interaction between medical implants and bone tissue and gives a future outlook for fabricating the next-generation multifunctional and smart implants by systematically biomimicking the physiological processes involved in formation and functioning of bones.",

keywords = "Bioactive coatings, Biomedical implants, Biomimetics, Bone tissue engineering",

author = "Chao Hu and D. Ashok and Nisbet, {David R.} and Vini Gautam",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = oct,

doi = "10.1016/j.biomaterials.2019.119366",

language = "English",

volume = "219",

journal = "Biomaterials",

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T1 - Bioinspired surface modification of orthopedic implants for bone tissue engineering

AU - Hu, Chao

AU - Ashok, D.

AU - Nisbet, David R.

AU - Gautam, Vini

PY - 2019/10

Y1 - 2019/10

N2 - Biomedical implants have been widely used in various orthopedic treatments, including total hip arthroplasty, joint arthrodesis, fracture fixation, non-union, dental repair, etc. The modern research and development of orthopedic implants have gradually shifted from traditional mechanical support to a bioactive graft in order to endow them with better osteoinduction and osteoconduction. Inspired by structural and mechanical properties of natural bone, this review provides a panorama of current biological surface modifications for facilitating the interaction between medical implants and bone tissue and gives a future outlook for fabricating the next-generation multifunctional and smart implants by systematically biomimicking the physiological processes involved in formation and functioning of bones.

AB - Biomedical implants have been widely used in various orthopedic treatments, including total hip arthroplasty, joint arthrodesis, fracture fixation, non-union, dental repair, etc. The modern research and development of orthopedic implants have gradually shifted from traditional mechanical support to a bioactive graft in order to endow them with better osteoinduction and osteoconduction. Inspired by structural and mechanical properties of natural bone, this review provides a panorama of current biological surface modifications for facilitating the interaction between medical implants and bone tissue and gives a future outlook for fabricating the next-generation multifunctional and smart implants by systematically biomimicking the physiological processes involved in formation and functioning of bones.

KW - Bioactive coatings

KW - Biomedical implants

KW - Biomimetics

KW - Bone tissue engineering

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DO - 10.1016/j.biomaterials.2019.119366

M3 - Review article

SN - 0142-9612

VL - 219

JO - Biomaterials

JF - Biomaterials

M1 - 119366

ER -

Bioinspired surface modification of orthopedic implants for bone tissue engineering

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