TY - JOUR
T1 - Biological evaluation of ent-narciclasine, ent-lycoricidine, and certain enantiomerically-related congeners
AU - Matveenko, Maria
AU - Banwell, Martin G.
AU - Joffe, Max
AU - Wan, Soosan
AU - Fantino, Emmanuelle
PY - 2009/5
Y1 - 2009/5
N2 - The non-natural enantiomeric forms of narciclasine and lycoricidine ((-)-1 and (-)-2, respectively), as well as congeners 3-6 are available through chemoenzymatic synthesis. Accordingly, they have now been tested for their cytotoxic effects in a 13-member human cancer cell-line panel and found to be only weakly active. In contrast, an authentic sample of the natural enantiomeric form of narciclasine ((+)-1) was found to be highly active in the same screens.
AB - The non-natural enantiomeric forms of narciclasine and lycoricidine ((-)-1 and (-)-2, respectively), as well as congeners 3-6 are available through chemoenzymatic synthesis. Accordingly, they have now been tested for their cytotoxic effects in a 13-member human cancer cell-line panel and found to be only weakly active. In contrast, an authentic sample of the natural enantiomeric form of narciclasine ((+)-1) was found to be highly active in the same screens.
UR - http://www.scopus.com/inward/record.url?scp=67649369572&partnerID=8YFLogxK
U2 - 10.1002/cbdv.200800319
DO - 10.1002/cbdv.200800319
M3 - Article
SN - 1612-1872
VL - 6
SP - 685
EP - 691
JO - Chemistry and Biodiversity
JF - Chemistry and Biodiversity
IS - 5
ER -