Biological evaluation of ent-narciclasine, ent-lycoricidine, and certain enantiomerically-related congeners

Maria Matveenko; Martin G. Banwell; Max Joffe; Soosan Wan; Emmanuelle Fantino

doi:10.1002/cbdv.200800319

Biological evaluation of ent-narciclasine, ent-lycoricidine, and certain enantiomerically-related congeners

Maria Matveenko, Martin G. Banwell, Max Joffe, Soosan Wan, Emmanuelle Fantino

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The non-natural enantiomeric forms of narciclasine and lycoricidine ((-)-1 and (-)-2, respectively), as well as congeners 3-6 are available through chemoenzymatic synthesis. Accordingly, they have now been tested for their cytotoxic effects in a 13-member human cancer cell-line panel and found to be only weakly active. In contrast, an authentic sample of the natural enantiomeric form of narciclasine ((+)-1) was found to be highly active in the same screens.

Original language	English
Pages (from-to)	685-691
Number of pages	7
Journal	Chemistry and Biodiversity
Volume	6
Issue number	5
DOIs	https://doi.org/10.1002/cbdv.200800319
Publication status	Published - May 2009

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abstract = "The non-natural enantiomeric forms of narciclasine and lycoricidine ((-)-1 and (-)-2, respectively), as well as congeners 3-6 are available through chemoenzymatic synthesis. Accordingly, they have now been tested for their cytotoxic effects in a 13-member human cancer cell-line panel and found to be only weakly active. In contrast, an authentic sample of the natural enantiomeric form of narciclasine ((+)-1) was found to be highly active in the same screens.",

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AU - Matveenko, Maria

AU - Banwell, Martin G.

AU - Joffe, Max

AU - Wan, Soosan

AU - Fantino, Emmanuelle

PY - 2009/5

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N2 - The non-natural enantiomeric forms of narciclasine and lycoricidine ((-)-1 and (-)-2, respectively), as well as congeners 3-6 are available through chemoenzymatic synthesis. Accordingly, they have now been tested for their cytotoxic effects in a 13-member human cancer cell-line panel and found to be only weakly active. In contrast, an authentic sample of the natural enantiomeric form of narciclasine ((+)-1) was found to be highly active in the same screens.

AB - The non-natural enantiomeric forms of narciclasine and lycoricidine ((-)-1 and (-)-2, respectively), as well as congeners 3-6 are available through chemoenzymatic synthesis. Accordingly, they have now been tested for their cytotoxic effects in a 13-member human cancer cell-line panel and found to be only weakly active. In contrast, an authentic sample of the natural enantiomeric form of narciclasine ((+)-1) was found to be highly active in the same screens.

UR - https://www.scopus.com/pages/publications/67649369572

U2 - 10.1002/cbdv.200800319

DO - 10.1002/cbdv.200800319

M3 - Article

SN - 1612-1872

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JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 5

ER -

Biological evaluation of ent-narciclasine, ent-lycoricidine, and certain enantiomerically-related congeners

Abstract

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