Biological pH sensing based on surface enhanced Raman scattering through a 2-aminothiophenol-silver probe

Zhuyuan Wang; Adela Bonoiu; Marek Samoc; Yiping Cui; Paras N. Prasad

doi:10.1016/j.bios.2007.09.017

Biological pH sensing based on surface enhanced Raman scattering through a 2-aminothiophenol-silver probe

Zhuyuan Wang, Adela Bonoiu, Marek Samoc, Yiping Cui, Paras N. Prasad^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

We report pH sensing for biological applications based on surface enhanced Raman scattering (SERS) from silver nanoparticles functionalized with 2-aminothiophenol (2-aminobenzenethiol, 2-ABT). pH-dependent SERS spectra of the attached 2-ABT molecules enable one to sense the pH over the range of 3.0-8.0. We have performed the first demonstration of SERS detection in living cells kept in different pH buffer solutions and show that the pH sensitivity is retained in that case. Thus, the nanoparticles can be used as probes delivering spatially localized chemical information from biological environments and provide a new way to monitor chemical changes at cellular level.

Original language	English
Pages (from-to)	886-891
Number of pages	6
Journal	Biosensors and Bioelectronics
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/j.bios.2007.09.017
Publication status	Published - 18 Jan 2008
Externally published	Yes

Access to Document

10.1016/j.bios.2007.09.017

Cite this

@article{daa38ddef77242a0a13267b6eaa1bb8f,

title = "Biological pH sensing based on surface enhanced Raman scattering through a 2-aminothiophenol-silver probe",

abstract = "We report pH sensing for biological applications based on surface enhanced Raman scattering (SERS) from silver nanoparticles functionalized with 2-aminothiophenol (2-aminobenzenethiol, 2-ABT). pH-dependent SERS spectra of the attached 2-ABT molecules enable one to sense the pH over the range of 3.0-8.0. We have performed the first demonstration of SERS detection in living cells kept in different pH buffer solutions and show that the pH sensitivity is retained in that case. Thus, the nanoparticles can be used as probes delivering spatially localized chemical information from biological environments and provide a new way to monitor chemical changes at cellular level.",

keywords = "Cellular imaging, SERS probe, Surface enhanced Raman scattering, pH sensor",

author = "Zhuyuan Wang and Adela Bonoiu and Marek Samoc and Yiping Cui and Prasad, {Paras N.}",

year = "2008",

month = jan,

day = "18",

doi = "10.1016/j.bios.2007.09.017",

language = "English",

volume = "23",

pages = "886--891",

journal = "Biosensors and Bioelectronics",

issn = "0956-5663",

publisher = "Elsevier Ltd.",

number = "6",

}

TY - JOUR

T1 - Biological pH sensing based on surface enhanced Raman scattering through a 2-aminothiophenol-silver probe

AU - Wang, Zhuyuan

AU - Bonoiu, Adela

AU - Samoc, Marek

AU - Cui, Yiping

AU - Prasad, Paras N.

PY - 2008/1/18

Y1 - 2008/1/18

N2 - We report pH sensing for biological applications based on surface enhanced Raman scattering (SERS) from silver nanoparticles functionalized with 2-aminothiophenol (2-aminobenzenethiol, 2-ABT). pH-dependent SERS spectra of the attached 2-ABT molecules enable one to sense the pH over the range of 3.0-8.0. We have performed the first demonstration of SERS detection in living cells kept in different pH buffer solutions and show that the pH sensitivity is retained in that case. Thus, the nanoparticles can be used as probes delivering spatially localized chemical information from biological environments and provide a new way to monitor chemical changes at cellular level.

AB - We report pH sensing for biological applications based on surface enhanced Raman scattering (SERS) from silver nanoparticles functionalized with 2-aminothiophenol (2-aminobenzenethiol, 2-ABT). pH-dependent SERS spectra of the attached 2-ABT molecules enable one to sense the pH over the range of 3.0-8.0. We have performed the first demonstration of SERS detection in living cells kept in different pH buffer solutions and show that the pH sensitivity is retained in that case. Thus, the nanoparticles can be used as probes delivering spatially localized chemical information from biological environments and provide a new way to monitor chemical changes at cellular level.

KW - Cellular imaging

KW - SERS probe

KW - Surface enhanced Raman scattering

KW - pH sensor

UR - http://www.scopus.com/inward/record.url?scp=37349050317&partnerID=8YFLogxK

U2 - 10.1016/j.bios.2007.09.017

DO - 10.1016/j.bios.2007.09.017

M3 - Article

SN - 0956-5663

VL - 23

SP - 886

EP - 891

JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

IS - 6

ER -

Biological pH sensing based on surface enhanced Raman scattering through a 2-aminothiophenol-silver probe

Abstract

Access to Document

Other files and links

Fingerprint

Cite this