Biomechanics of chiasmal compression: Sensitivity of the mechanical behaviours of nerve fibres to variations in material property and geometry

Xiaofei Wang; Andrew J. Neely; Gawn G. Mcilwaine; Christian J. Lueck

Biomechanics of chiasmal compression: Sensitivity of the mechanical behaviours of nerve fibres to variations in material property and geometry

Xiaofei Wang, Andrew J. Neely, Gawn G. Mcilwaine, Christian J. Lueck

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The mechanism of bitemporal hemianopia is still unclear. Previous research suggested that the nerve fibre packing pattern may contribute to the selective damage of nasal (crossed) nerve fibres. Numerical models were built using finite element modelling to study the biomechanics of optic nerve fibres. The sensitivity of the mechanical behaviours of the nerve fibres to variations of five parameters in the nerve fibre model were investigated using design of experiments (DOE). Results show that the crossing angle is a very significant factor that affects a wide range of responses of the model. The strain difference between the crossed and the uncrossed nerve fibres may account for the phenomenon of bitemporal hemianopia. This work also highlights the need for more accurate material properties of the tissues in the model and an improved understanding of the microstructure of the optic chiasm.

Original language	English
Title of host publication	11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014
Editors	Eugenio Onate, Xavier Oliver, Antonio Huerta
Publisher	International Center for Numerical Methods in Engineering
Pages	1688-1697
Number of pages	10
ISBN (Electronic)	9788494284472
Publication status	Published - 1 Jul 2014
Event	Joint 11th World Congress on Computational Mechanics, WCCM 2014, the 5th European Conference on Computational Mechanics, ECCM 2014 and the 6th European Conference on Computational Fluid Dynamics, ECFD 2014 - Barcelona, Spain Duration: 20 Jul 2014 → 25 Jul 2014

Publication series

Name	11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014

Conference

Conference	Joint 11th World Congress on Computational Mechanics, WCCM 2014, the 5th European Conference on Computational Mechanics, ECCM 2014 and the 6th European Conference on Computational Fluid Dynamics, ECFD 2014
Country/Territory	Spain
City	Barcelona
Period	20/07/14 → 25/07/14

Cite this

Wang, X., Neely, A. J., Mcilwaine, G. G., & Lueck, C. J. (2014). Biomechanics of chiasmal compression: Sensitivity of the mechanical behaviours of nerve fibres to variations in material property and geometry. In E. Onate, X. Oliver, & A. Huerta (Eds.), 11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014 (pp. 1688-1697). (11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014). International Center for Numerical Methods in Engineering.

Wang, Xiaofei ; Neely, Andrew J. ; Mcilwaine, Gawn G. et al. / Biomechanics of chiasmal compression : Sensitivity of the mechanical behaviours of nerve fibres to variations in material property and geometry. 11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014. editor / Eugenio Onate ; Xavier Oliver ; Antonio Huerta. International Center for Numerical Methods in Engineering, 2014. pp. 1688-1697 (11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014).

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title = "Biomechanics of chiasmal compression: Sensitivity of the mechanical behaviours of nerve fibres to variations in material property and geometry",

abstract = "The mechanism of bitemporal hemianopia is still unclear. Previous research suggested that the nerve fibre packing pattern may contribute to the selective damage of nasal (crossed) nerve fibres. Numerical models were built using finite element modelling to study the biomechanics of optic nerve fibres. The sensitivity of the mechanical behaviours of the nerve fibres to variations of five parameters in the nerve fibre model were investigated using design of experiments (DOE). Results show that the crossing angle is a very significant factor that affects a wide range of responses of the model. The strain difference between the crossed and the uncrossed nerve fibres may account for the phenomenon of bitemporal hemianopia. This work also highlights the need for more accurate material properties of the tissues in the model and an improved understanding of the microstructure of the optic chiasm.",

keywords = "Bitemporal hemianopia, Chiasmal compression, Design of experiment, Finite element modelling, Multi-scale",

author = "Xiaofei Wang and Neely, {Andrew J.} and Mcilwaine, {Gawn G.} and Lueck, {Christian J.}",

year = "2014",

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language = "English",

series = "11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014",

publisher = "International Center for Numerical Methods in Engineering",

pages = "1688--1697",

editor = "Eugenio Onate and Xavier Oliver and Antonio Huerta",

booktitle = "11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014",

note = "Joint 11th World Congress on Computational Mechanics, WCCM 2014, the 5th European Conference on Computational Mechanics, ECCM 2014 and the 6th European Conference on Computational Fluid Dynamics, ECFD 2014 ; Conference date: 20-07-2014 Through 25-07-2014",

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Wang, X, Neely, AJ, Mcilwaine, GG & Lueck, CJ 2014, Biomechanics of chiasmal compression: Sensitivity of the mechanical behaviours of nerve fibres to variations in material property and geometry. in E Onate, X Oliver & A Huerta (eds), 11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014. 11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014, International Center for Numerical Methods in Engineering, pp. 1688-1697, Joint 11th World Congress on Computational Mechanics, WCCM 2014, the 5th European Conference on Computational Mechanics, ECCM 2014 and the 6th European Conference on Computational Fluid Dynamics, ECFD 2014, Barcelona, Spain, 20/07/14.

Biomechanics of chiasmal compression: Sensitivity of the mechanical behaviours of nerve fibres to variations in material property and geometry. / Wang, Xiaofei; Neely, Andrew J.; Mcilwaine, Gawn G. et al.
11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014. ed. / Eugenio Onate; Xavier Oliver; Antonio Huerta. International Center for Numerical Methods in Engineering, 2014. p. 1688-1697 (11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Biomechanics of chiasmal compression

T2 - Joint 11th World Congress on Computational Mechanics, WCCM 2014, the 5th European Conference on Computational Mechanics, ECCM 2014 and the 6th European Conference on Computational Fluid Dynamics, ECFD 2014

AU - Wang, Xiaofei

AU - Neely, Andrew J.

AU - Mcilwaine, Gawn G.

AU - Lueck, Christian J.

PY - 2014/7/1

Y1 - 2014/7/1

N2 - The mechanism of bitemporal hemianopia is still unclear. Previous research suggested that the nerve fibre packing pattern may contribute to the selective damage of nasal (crossed) nerve fibres. Numerical models were built using finite element modelling to study the biomechanics of optic nerve fibres. The sensitivity of the mechanical behaviours of the nerve fibres to variations of five parameters in the nerve fibre model were investigated using design of experiments (DOE). Results show that the crossing angle is a very significant factor that affects a wide range of responses of the model. The strain difference between the crossed and the uncrossed nerve fibres may account for the phenomenon of bitemporal hemianopia. This work also highlights the need for more accurate material properties of the tissues in the model and an improved understanding of the microstructure of the optic chiasm.

AB - The mechanism of bitemporal hemianopia is still unclear. Previous research suggested that the nerve fibre packing pattern may contribute to the selective damage of nasal (crossed) nerve fibres. Numerical models were built using finite element modelling to study the biomechanics of optic nerve fibres. The sensitivity of the mechanical behaviours of the nerve fibres to variations of five parameters in the nerve fibre model were investigated using design of experiments (DOE). Results show that the crossing angle is a very significant factor that affects a wide range of responses of the model. The strain difference between the crossed and the uncrossed nerve fibres may account for the phenomenon of bitemporal hemianopia. This work also highlights the need for more accurate material properties of the tissues in the model and an improved understanding of the microstructure of the optic chiasm.

KW - Bitemporal hemianopia

KW - Chiasmal compression

KW - Design of experiment

KW - Finite element modelling

KW - Multi-scale

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M3 - Conference contribution

T3 - 11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014

SP - 1688

EP - 1697

BT - 11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014

A2 - Onate, Eugenio

A2 - Oliver, Xavier

A2 - Huerta, Antonio

PB - International Center for Numerical Methods in Engineering

Y2 - 20 July 2014 through 25 July 2014

ER -

Wang X, Neely AJ, Mcilwaine GG, Lueck CJ. Biomechanics of chiasmal compression: Sensitivity of the mechanical behaviours of nerve fibres to variations in material property and geometry. In Onate E, Oliver X, Huerta A, editors, 11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014. International Center for Numerical Methods in Engineering. 2014. p. 1688-1697. (11th World Congress on Computational Mechanics, WCCM 2014, 5th European Conference on Computational Mechanics, ECCM 2014 and 6th European Conference on Computational Fluid Dynamics, ECFD 2014).

Biomechanics of chiasmal compression: Sensitivity of the mechanical behaviours of nerve fibres to variations in material property and geometry

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