Blood oxygenation changes resulting from suprathreshold transcranial magnetic stimulation

Richard H. Thomson; Jerome J. Maller; Zafiris J. Daskalakis; Paul B. Fitzgerald

doi:10.1016/j.brs.2010.10.003

Blood oxygenation changes resulting from suprathreshold transcranial magnetic stimulation

Richard H. Thomson, Jerome J. Maller, Zafiris J. Daskalakis, Paul B. Fitzgerald^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

The hemodynamic response to low-intensity transcranial magnetic stimulation (TMS) has previously been demonstrated at motor cortex using near infrared spectroscopy (NIRS). To investigate the effect of TMS on oxy-hemoglobin (HbO) at prefrontal cortex, both subthreshold and suprathreshold TMS relative to resting motor threshold (rMT) were applied at typical intensities used in experimental settings. Although there was no significant change after 90% and 110% rMT TMS, there was a significant drop in HbO after 130% rMT TMS. This drop was maximal at approximately 8 seconds post-TMS. This study may have implications for determining appropriate TMS intensities when stimulating nonmotor areas.

Original language	English
Pages (from-to)	165-168
Number of pages	4
Journal	Brain Stimulation
Volume	4
Issue number	3
DOIs	https://doi.org/10.1016/j.brs.2010.10.003
Publication status	Published - Jul 2011
Externally published	Yes

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10.1016/j.brs.2010.10.003

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title = "Blood oxygenation changes resulting from suprathreshold transcranial magnetic stimulation",

abstract = "The hemodynamic response to low-intensity transcranial magnetic stimulation (TMS) has previously been demonstrated at motor cortex using near infrared spectroscopy (NIRS). To investigate the effect of TMS on oxy-hemoglobin (HbO) at prefrontal cortex, both subthreshold and suprathreshold TMS relative to resting motor threshold (rMT) were applied at typical intensities used in experimental settings. Although there was no significant change after 90% and 110% rMT TMS, there was a significant drop in HbO after 130% rMT TMS. This drop was maximal at approximately 8 seconds post-TMS. This study may have implications for determining appropriate TMS intensities when stimulating nonmotor areas.",

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author = "Thomson, {Richard H.} and Maller, {Jerome J.} and Daskalakis, {Zafiris J.} and Fitzgerald, {Paul B.}",

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AU - Maller, Jerome J.

AU - Daskalakis, Zafiris J.

AU - Fitzgerald, Paul B.

PY - 2011/7

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N2 - The hemodynamic response to low-intensity transcranial magnetic stimulation (TMS) has previously been demonstrated at motor cortex using near infrared spectroscopy (NIRS). To investigate the effect of TMS on oxy-hemoglobin (HbO) at prefrontal cortex, both subthreshold and suprathreshold TMS relative to resting motor threshold (rMT) were applied at typical intensities used in experimental settings. Although there was no significant change after 90% and 110% rMT TMS, there was a significant drop in HbO after 130% rMT TMS. This drop was maximal at approximately 8 seconds post-TMS. This study may have implications for determining appropriate TMS intensities when stimulating nonmotor areas.

AB - The hemodynamic response to low-intensity transcranial magnetic stimulation (TMS) has previously been demonstrated at motor cortex using near infrared spectroscopy (NIRS). To investigate the effect of TMS on oxy-hemoglobin (HbO) at prefrontal cortex, both subthreshold and suprathreshold TMS relative to resting motor threshold (rMT) were applied at typical intensities used in experimental settings. Although there was no significant change after 90% and 110% rMT TMS, there was a significant drop in HbO after 130% rMT TMS. This drop was maximal at approximately 8 seconds post-TMS. This study may have implications for determining appropriate TMS intensities when stimulating nonmotor areas.

KW - brain stimulation

KW - cortical blood flow

KW - oxygenated hemoglobin

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KW - transcranial magnetic stimulation

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JO - Brain Stimulation

JF - Brain Stimulation

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ER -

Blood oxygenation changes resulting from suprathreshold transcranial magnetic stimulation

Abstract

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