Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease

Kaarin J. Anstey; Alex Bahar-Fuchs; Pushpani Herath; Sarang Kim; Richard Burns; George W. Rebok; Nicolas Cherbuin

doi:10.1016/j.trci.2015.04.003

Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease

Kaarin J. Anstey^*, Alex Bahar-Fuchs, Pushpani Herath, Sarang Kim, Richard Burns, George W. Rebok, Nicolas Cherbuin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Objective To examine the efficacy of body brain life (BBL), a 12-week online dementia risk reduction intervention. Methods BBL was evaluated in a randomized controlled trial in 176 middle-aged adults with >2 risk factors and <2 protective factors for Alzheimer's disease (AD) assessed on a brief screening instrument. Participants were randomized to BBL, BBL plus face-to-face group sessions (BBL + FF) or active control (control). Score on the Australian National University-Alzheimer's disease risk index (ANU-ADRI), a validated index of AD risk, was the primary outcome measure assessed at baseline, 12, and 26 weeks. Results A group by time interaction at 26 weeks showed a significant reduction in ANU-ADRI score for BBL compared with control. Planned contrasts showed the BBL and BBL + FF groups had improvement in ANU-ADRI scores at 12 weeks (BBL + FF: z = -0.25; P =.021; BBL: z = -0.25; P =.008) and 26 weeks (BBL + FF: z = -0.48; P <.001; BBL: z = -0.28; P =.004) due to increase in protective factors. Conclusions This short intervention resulted in dementia risk reduction. Online dementia risk reduction interventions show promise for reducing the overall dementia risk in middle-aged adults with multiple risk factors. Clinical Trial Registration: The study is registered under Trial Registration: Reg. # ACTRN12612000147886.

Original language	English
Pages (from-to)	72-80
Number of pages	9
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/j.trci.2015.04.003
Publication status	Published - 14 Oct 2015

Access to Document

10.1016/j.trci.2015.04.003

Cite this

Anstey, K. J., Bahar-Fuchs, A., Herath, P., Kim, S., Burns, R., Rebok, G. W., & Cherbuin, N. (2015). Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 1(1), 72-80. https://doi.org/10.1016/j.trci.2015.04.003

@article{c135e4e6a97f4d4090498d3e15409493,

title = "Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease",

abstract = "Objective To examine the efficacy of body brain life (BBL), a 12-week online dementia risk reduction intervention. Methods BBL was evaluated in a randomized controlled trial in 176 middle-aged adults with >2 risk factors and <2 protective factors for Alzheimer's disease (AD) assessed on a brief screening instrument. Participants were randomized to BBL, BBL plus face-to-face group sessions (BBL + FF) or active control (control). Score on the Australian National University-Alzheimer's disease risk index (ANU-ADRI), a validated index of AD risk, was the primary outcome measure assessed at baseline, 12, and 26 weeks. Results A group by time interaction at 26 weeks showed a significant reduction in ANU-ADRI score for BBL compared with control. Planned contrasts showed the BBL and BBL + FF groups had improvement in ANU-ADRI scores at 12 weeks (BBL + FF: z = -0.25; P =.021; BBL: z = -0.25; P =.008) and 26 weeks (BBL + FF: z = -0.48; P <.001; BBL: z = -0.28; P =.004) due to increase in protective factors. Conclusions This short intervention resulted in dementia risk reduction. Online dementia risk reduction interventions show promise for reducing the overall dementia risk in middle-aged adults with multiple risk factors. Clinical Trial Registration: The study is registered under Trial Registration: Reg. # ACTRN12612000147886.",

keywords = "Behavior change, Cognitive activity, Dementia prevention, Intervention, Risk factor, Risk reduction, Social engagement",

author = "Anstey, {Kaarin J.} and Alex Bahar-Fuchs and Pushpani Herath and Sarang Kim and Richard Burns and Rebok, {George W.} and Nicolas Cherbuin",

note = "Publisher Copyright: {\textcopyright} 2015 The Authors.",

year = "2015",

month = oct,

day = "14",

doi = "10.1016/j.trci.2015.04.003",

language = "English",

volume = "1",

pages = "72--80",

journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",

issn = "2352-8737",

publisher = "John Wiley & Sons Inc.",

number = "1",

}

Anstey, KJ, Bahar-Fuchs, A, Herath, P, Kim, S, Burns, R, Rebok, GW & Cherbuin, N 2015, 'Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 1, no. 1, pp. 72-80. https://doi.org/10.1016/j.trci.2015.04.003

Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease. / Anstey, Kaarin J.; Bahar-Fuchs, Alex; Herath, Pushpani et al.
In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 1, No. 1, 14.10.2015, p. 72-80.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Body brain life

T2 - A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease

AU - Anstey, Kaarin J.

AU - Bahar-Fuchs, Alex

AU - Herath, Pushpani

AU - Kim, Sarang

AU - Burns, Richard

AU - Rebok, George W.

AU - Cherbuin, Nicolas

PY - 2015/10/14

Y1 - 2015/10/14

N2 - Objective To examine the efficacy of body brain life (BBL), a 12-week online dementia risk reduction intervention. Methods BBL was evaluated in a randomized controlled trial in 176 middle-aged adults with >2 risk factors and <2 protective factors for Alzheimer's disease (AD) assessed on a brief screening instrument. Participants were randomized to BBL, BBL plus face-to-face group sessions (BBL + FF) or active control (control). Score on the Australian National University-Alzheimer's disease risk index (ANU-ADRI), a validated index of AD risk, was the primary outcome measure assessed at baseline, 12, and 26 weeks. Results A group by time interaction at 26 weeks showed a significant reduction in ANU-ADRI score for BBL compared with control. Planned contrasts showed the BBL and BBL + FF groups had improvement in ANU-ADRI scores at 12 weeks (BBL + FF: z = -0.25; P =.021; BBL: z = -0.25; P =.008) and 26 weeks (BBL + FF: z = -0.48; P <.001; BBL: z = -0.28; P =.004) due to increase in protective factors. Conclusions This short intervention resulted in dementia risk reduction. Online dementia risk reduction interventions show promise for reducing the overall dementia risk in middle-aged adults with multiple risk factors. Clinical Trial Registration: The study is registered under Trial Registration: Reg. # ACTRN12612000147886.

AB - Objective To examine the efficacy of body brain life (BBL), a 12-week online dementia risk reduction intervention. Methods BBL was evaluated in a randomized controlled trial in 176 middle-aged adults with >2 risk factors and <2 protective factors for Alzheimer's disease (AD) assessed on a brief screening instrument. Participants were randomized to BBL, BBL plus face-to-face group sessions (BBL + FF) or active control (control). Score on the Australian National University-Alzheimer's disease risk index (ANU-ADRI), a validated index of AD risk, was the primary outcome measure assessed at baseline, 12, and 26 weeks. Results A group by time interaction at 26 weeks showed a significant reduction in ANU-ADRI score for BBL compared with control. Planned contrasts showed the BBL and BBL + FF groups had improvement in ANU-ADRI scores at 12 weeks (BBL + FF: z = -0.25; P =.021; BBL: z = -0.25; P =.008) and 26 weeks (BBL + FF: z = -0.48; P <.001; BBL: z = -0.28; P =.004) due to increase in protective factors. Conclusions This short intervention resulted in dementia risk reduction. Online dementia risk reduction interventions show promise for reducing the overall dementia risk in middle-aged adults with multiple risk factors. Clinical Trial Registration: The study is registered under Trial Registration: Reg. # ACTRN12612000147886.

KW - Behavior change

KW - Cognitive activity

KW - Dementia prevention

KW - Intervention

KW - Risk factor

KW - Risk reduction

KW - Social engagement

UR - http://www.scopus.com/inward/record.url?scp=84943806746&partnerID=8YFLogxK

U2 - 10.1016/j.trci.2015.04.003

DO - 10.1016/j.trci.2015.04.003

M3 - Article

SN - 2352-8737

VL - 1

SP - 72

EP - 80

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

IS - 1

ER -

Body brain life: A randomized controlled trial of an online dementia risk reduction intervention in middle-aged adults at risk of Alzheimer's disease

Abstract

Access to Document

Other files and links

Fingerprint

Cite this