Body mass index is associated with cortical thinning with different patterns in mid- and late-life

M. E. Shaw*, P. S. Sachdev, W. Abhayaratna, K. J. Anstey, N. Cherbuin

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    46 Citations (Scopus)


    Objective:High BMI at midlife is associated with increased risk of dementia as well as faster decline in cognitive function. In late-life, however, high BMI has been found to be associated with both increased and decreased dementia risk. The objective of this study was to investigate the neural substrates of this age-related change in body mass index (BMI) risk.Methods:We measured longitudinal cortical thinning over the whole brain, based on magnetic resonance imaging scans for 910 individuals aged 44-66 years at baseline. Subjects were sampled from a large population study (PATH, Personality and Total Health through Life). After attrition and exclusions, the final analysis was based on 792 individuals, including 387 individuals aged 60-66 years and 405 individuals aged 44-49 years. A mixed-effects model was used to test the association between cortical thinning and baseline BMI, as well as percentage change in BMI.Results:Increasing BMI was associated with increased cortical thinning in posterior cingulate at midlife (0.014 mm kg '1 m '2, confidence interval; CI=0.005, 0.023, P<0.05 false discovery rate (FDR) corrected). In late-life, increasing BMI was associated with reduced cortical thickness, most prominently in the right supramarginal cortex (0.010 mm kg '1 m '2, CI=0.005-0.016, P<0.05 FDR corrected), as well as frontal regions. In late-life, decreasing BMI was also associated with increased cortical thinning, including right caudal middle frontal cortex (0.014 mm kg '1 m '2 (CI=0.006-0.023, P<0.05 FDR corrected).Conclusions:The pattern of cortical thinning - in association with increasing BMI at both midlife and late-life - is consistent with known obesity-related dementia risk. Increased cortical thinning in association with decreasing BMI at late-life may help explain the 'obesity paradox', where high BMI in midlife appears to be a risk factor for dementia, but high BMI in late-life appears, at times, to be protective.

    Original languageEnglish
    Pages (from-to)455-461
    Number of pages7
    JournalInternational Journal of Obesity
    Issue number3
    Publication statusPublished - 1 Mar 2018


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