Brain plasticity, memory and neurological disorders: An epigenetic perspective

Gabrielle A. Lockett; Fiona Wilkes; Ryszard Maleszka

doi:10.1097/WNR.0b013e32833e9288

Brain plasticity, memory and neurological disorders: An epigenetic perspective

Gabrielle A. Lockett, Fiona Wilkes, Ryszard Maleszka^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

33 Citations (Scopus)

Abstract

Epigenomic settings control gene regulation in both developing and postmitotic tissue, whereas abnormal regulation of epigenomic settings has been implicated in many developmental and neurological disorders. Evidence is emerging for the roles of epigenetic mechanisms in the mature nervous system, in the dynamic processes of learning and memory. The discovery of the involvement of DNA methylation and histone acetylation and methylation in neuronal processing provides a possible answer to the long-standing riddle of how memories persist in a biological system whose cellular composition is in a constant state of flux and renewal. This mini review focuses on present research in DNA methylation and histone posttranslational modifications in learning and memory, age-related cognitive decline, and related pathological disorders.

Original language	English
Pages (from-to)	909-913
Number of pages	5
Journal	NeuroReport
Volume	21
Issue number	14
DOIs	https://doi.org/10.1097/WNR.0b013e32833e9288
Publication status	Published - 6 Oct 2010

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abstract = "Epigenomic settings control gene regulation in both developing and postmitotic tissue, whereas abnormal regulation of epigenomic settings has been implicated in many developmental and neurological disorders. Evidence is emerging for the roles of epigenetic mechanisms in the mature nervous system, in the dynamic processes of learning and memory. The discovery of the involvement of DNA methylation and histone acetylation and methylation in neuronal processing provides a possible answer to the long-standing riddle of how memories persist in a biological system whose cellular composition is in a constant state of flux and renewal. This mini review focuses on present research in DNA methylation and histone posttranslational modifications in learning and memory, age-related cognitive decline, and related pathological disorders.",

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AU - Maleszka, Ryszard

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AB - Epigenomic settings control gene regulation in both developing and postmitotic tissue, whereas abnormal regulation of epigenomic settings has been implicated in many developmental and neurological disorders. Evidence is emerging for the roles of epigenetic mechanisms in the mature nervous system, in the dynamic processes of learning and memory. The discovery of the involvement of DNA methylation and histone acetylation and methylation in neuronal processing provides a possible answer to the long-standing riddle of how memories persist in a biological system whose cellular composition is in a constant state of flux and renewal. This mini review focuses on present research in DNA methylation and histone posttranslational modifications in learning and memory, age-related cognitive decline, and related pathological disorders.

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KW - ageing

KW - histone modification

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KW - learning

KW - memory

KW - neurodegeneration

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Brain plasticity, memory and neurological disorders: An epigenetic perspective

Abstract

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