Bridgehead Arylation: A Direct Route to Advanced Intermediates for the Synthesis of C-20 Diterpene Alkaloids

Craig M. Williams; Lewis N. Mander

doi:10.1021/ol0353060

Bridgehead Arylation: A Direct Route to Advanced Intermediates for the Synthesis of C-20 Diterpene Alkaloids

Craig M. Williams^*, Lewis N. Mander

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Equation presented. Rapid access to the ABCE ring system of the C ₂₀ diterpene alkaloids was achieved by silver(I)-promoted intramolecular Friedel-Crafts arylation of a functional group-specific 5-bromo-3-azabicyclo[3.3.1]nonane derivative.

Original language	English
Pages (from-to)	3499-3502
Number of pages	4
Journal	Organic Letters
Volume	5
Issue number	19
DOIs	https://doi.org/10.1021/ol0353060
Publication status	Published - 18 Sept 2003

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title = "Bridgehead Arylation: A Direct Route to Advanced Intermediates for the Synthesis of C-20 Diterpene Alkaloids",

abstract = "Equation presented. Rapid access to the ABCE ring system of the C 20 diterpene alkaloids was achieved by silver(I)-promoted intramolecular Friedel-Crafts arylation of a functional group-specific 5-bromo-3-azabicyclo[3.3.1]nonane derivative.",

author = "Williams, {Craig M.} and Mander, {Lewis N.}",

year = "2003",

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AU - Williams, Craig M.

AU - Mander, Lewis N.

PY - 2003/9/18

Y1 - 2003/9/18

N2 - Equation presented. Rapid access to the ABCE ring system of the C 20 diterpene alkaloids was achieved by silver(I)-promoted intramolecular Friedel-Crafts arylation of a functional group-specific 5-bromo-3-azabicyclo[3.3.1]nonane derivative.

AB - Equation presented. Rapid access to the ABCE ring system of the C 20 diterpene alkaloids was achieved by silver(I)-promoted intramolecular Friedel-Crafts arylation of a functional group-specific 5-bromo-3-azabicyclo[3.3.1]nonane derivative.

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U2 - 10.1021/ol0353060

DO - 10.1021/ol0353060

M3 - Article

SN - 1523-7060

VL - 5

SP - 3499

EP - 3502

JO - Organic Letters

JF - Organic Letters

IS - 19

ER -

Bridgehead Arylation: A Direct Route to Advanced Intermediates for the Synthesis of C-20 Diterpene Alkaloids

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