Abstract
Three-dimensional Brownian dynamics simulations are used to study conductance of the KcsA potassium channel using the known crystallographic structure. Employing an open-state channel created by molecular dynamics simulations, current-voltage and current-concentration curves broadly consistent with experimental measurements are obtained. In the absence of an applied potential, the channel houses three potassium ions at positions that are in close agreement with X-ray diffraction maps.
Original language | English |
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Pages (from-to) | 83-91 |
Number of pages | 9 |
Journal | Biochimica et Biophysica Acta - Biomembranes |
Volume | 1515 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Dec 2001 |