Brownian dynamics study of an open-state KcsA potassium channel

T. W. Allen, S. H. Chung*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    63 Citations (Scopus)

    Abstract

    Three-dimensional Brownian dynamics simulations are used to study conductance of the KcsA potassium channel using the known crystallographic structure. Employing an open-state channel created by molecular dynamics simulations, current-voltage and current-concentration curves broadly consistent with experimental measurements are obtained. In the absence of an applied potential, the channel houses three potassium ions at positions that are in close agreement with X-ray diffraction maps.

    Original languageEnglish
    Pages (from-to)83-91
    Number of pages9
    JournalBiochimica et Biophysica Acta - Biomembranes
    Volume1515
    Issue number2
    DOIs
    Publication statusPublished - 1 Dec 2001

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