Brownian dynamics study of an open-state KcsA potassium channel

T. W. Allen; S. H. Chung

doi:10.1016/S0005-2736(01)00395-9

Brownian dynamics study of an open-state KcsA potassium channel

T. W. Allen, S. H. Chung^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Three-dimensional Brownian dynamics simulations are used to study conductance of the KcsA potassium channel using the known crystallographic structure. Employing an open-state channel created by molecular dynamics simulations, current-voltage and current-concentration curves broadly consistent with experimental measurements are obtained. In the absence of an applied potential, the channel houses three potassium ions at positions that are in close agreement with X-ray diffraction maps.

Original language	English
Pages (from-to)	83-91
Number of pages	9
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	1515
Issue number	2
DOIs	https://doi.org/10.1016/S0005-2736(01)00395-9
Publication status	Published - 1 Dec 2001

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10.1016/S0005-2736(01)00395-9

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title = "Brownian dynamics study of an open-state KcsA potassium channel",

abstract = "Three-dimensional Brownian dynamics simulations are used to study conductance of the KcsA potassium channel using the known crystallographic structure. Employing an open-state channel created by molecular dynamics simulations, current-voltage and current-concentration curves broadly consistent with experimental measurements are obtained. In the absence of an applied potential, the channel houses three potassium ions at positions that are in close agreement with X-ray diffraction maps.",

keywords = "Brownian dynamics, Conductance, Molecular dynamics, Potassium channel",

author = "Allen, \{T. W.\} and Chung, \{S. H.\}",

year = "2001",

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doi = "10.1016/S0005-2736(01)00395-9",

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AU - Allen, T. W.

AU - Chung, S. H.

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Three-dimensional Brownian dynamics simulations are used to study conductance of the KcsA potassium channel using the known crystallographic structure. Employing an open-state channel created by molecular dynamics simulations, current-voltage and current-concentration curves broadly consistent with experimental measurements are obtained. In the absence of an applied potential, the channel houses three potassium ions at positions that are in close agreement with X-ray diffraction maps.

AB - Three-dimensional Brownian dynamics simulations are used to study conductance of the KcsA potassium channel using the known crystallographic structure. Employing an open-state channel created by molecular dynamics simulations, current-voltage and current-concentration curves broadly consistent with experimental measurements are obtained. In the absence of an applied potential, the channel houses three potassium ions at positions that are in close agreement with X-ray diffraction maps.

KW - Brownian dynamics

KW - Conductance

KW - Molecular dynamics

KW - Potassium channel

UR - https://www.scopus.com/pages/publications/0035575826

U2 - 10.1016/S0005-2736(01)00395-9

DO - 10.1016/S0005-2736(01)00395-9

M3 - Article

SN - 0005-2736

VL - 1515

SP - 83

EP - 91

JO - Biochimica et Biophysica Acta - Biomembranes

JF - Biochimica et Biophysica Acta - Biomembranes

IS - 2

ER -

Brownian dynamics study of an open-state KcsA potassium channel

Abstract

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