c-Fos transrepression revisited

Michael A. Cahill

doi:10.1016/S0014-5793(96)01349-X

c-Fos transrepression revisited

Michael A. Cahill^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The c-fos proto-oncogene was discovered by homology to transforming viral genes, leading to speculation that transforming viruses had captured a cellular gene involved in cell cycle control. Indeed overexpression of c-Fos protein led to deregulated growth control, and c-Fos was thought to be so critically involved in cell cycle control that transcriptional transrepression of its own promoter was interpreted as a negative feedback mechanism. However, recent findings render this conclusion improbable, Fos transrepression being most parsimoniously explained as transcriptional squelching imposed by artificially elevated levels of exogenous Fos protein.

Original language	English
Pages (from-to)	9-10
Number of pages	2
Journal	FEBS Letters
Volume	400
Issue number	1
DOIs	https://doi.org/10.1016/S0014-5793(96)01349-X
Publication status	Published - 2 Jan 1997

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10.1016/S0014-5793(96)01349-X

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AB - The c-fos proto-oncogene was discovered by homology to transforming viral genes, leading to speculation that transforming viruses had captured a cellular gene involved in cell cycle control. Indeed overexpression of c-Fos protein led to deregulated growth control, and c-Fos was thought to be so critically involved in cell cycle control that transcriptional transrepression of its own promoter was interpreted as a negative feedback mechanism. However, recent findings render this conclusion improbable, Fos transrepression being most parsimoniously explained as transcriptional squelching imposed by artificially elevated levels of exogenous Fos protein.

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c-Fos transrepression revisited

Abstract

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