TY - JOUR
T1 - C8c-C15 monoseco-analogues of the phenanthroquinolizidine alkaloids julandine and cryptopleurine exhibiting potent anti-angiogenic properties
AU - Banwell, Martin G.
AU - Bezos, Anna
AU - Burns, Christopher
AU - Kruszelnicki, Irma
AU - Parish, Christopher R.
AU - Su, Stephen
AU - Sydnes, Magne O.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Four enantiomerically pure monoseco-analogues, 5, 7, 9, and 11, of the phenanthroquinolizidine alkaloid julandine (1) and four of congener cryptopleurine (2), viz. compounds 6, 8, 10, and 12, have been prepared and subjected to preliminary biological evaluation. These analogues show dramatically reduced cytotoxicity compared with the parent system 2 but they are, nevertheless, potent anti-angiogenic agents.
AB - Four enantiomerically pure monoseco-analogues, 5, 7, 9, and 11, of the phenanthroquinolizidine alkaloid julandine (1) and four of congener cryptopleurine (2), viz. compounds 6, 8, 10, and 12, have been prepared and subjected to preliminary biological evaluation. These analogues show dramatically reduced cytotoxicity compared with the parent system 2 but they are, nevertheless, potent anti-angiogenic agents.
KW - Anti-angiogenic
KW - Combretastatin A4
KW - Phenanthroquinolizidine
KW - cis-Stilbene
UR - http://www.scopus.com/inward/record.url?scp=27744523400&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2005.09.032
DO - 10.1016/j.bmcl.2005.09.032
M3 - Article
SN - 0960-894X
VL - 16
SP - 181
EP - 185
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 1
ER -