Captain GBP1: inflammasomes assemble, pyroptotic endgame

Shouya Feng; Si Ming Man

doi:10.1038/s41590-020-0727-0

Captain GBP1: inflammasomes assemble, pyroptotic endgame

Shouya Feng, Si Ming Man^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

10 Citations (Scopus)

Abstract

Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.

Original language	English
Pages (from-to)	829-830
Number of pages	2
Journal	Nature Immunology
Volume	21
Issue number	8
DOIs	https://doi.org/10.1038/s41590-020-0727-0
Publication status	Published - 1 Aug 2020

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title = "Captain GBP1: inflammasomes assemble, pyroptotic endgame",

abstract = "Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.",

author = "Shouya Feng and Man, {Si Ming}",

year = "2020",

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doi = "10.1038/s41590-020-0727-0",

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T2 - inflammasomes assemble, pyroptotic endgame

AU - Feng, Shouya

AU - Man, Si Ming

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N2 - Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.

AB - Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.

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U2 - 10.1038/s41590-020-0727-0

DO - 10.1038/s41590-020-0727-0

M3 - Comment/debate

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VL - 21

SP - 829

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JO - Nature Immunology

JF - Nature Immunology

IS - 8

ER -

Captain GBP1: inflammasomes assemble, pyroptotic endgame

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