Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF

Yves Brandenburger; Jane F. Arthur; Elizabeth A. Woodcock; Xiao Jun Du; Xiao Ming Gao; Dominic J. Autelitano; Lawrence I. Rothblum; Ross D. Hannan

doi:10.1016/S0014-5793(03)00744-0

Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF

Yves Brandenburger, Jane F. Arthur, Elizabeth A. Woodcock, Xiao Jun Du, Xiao Ming Gao, Dominic J. Autelitano, Lawrence I. Rothblum, Ross D. Hannan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The ribosomal DNA transcription-specific factor, UBF, is a key target for the regulation of ribosomal RNA synthesis and hypertrophic growth of isolated neonatal cardiomyocytes. In this study, we have examined whether UBF expression is also an important determinant of cardiac growth rates in vivo. We show that rDNA transcription, rRNA synthesis and UBF expression in left ventricular myocytes isolated from mice 1-6 weeks following transverse aortic constriction were significantly increased (2.5-3.5-fold) compared to the levels in myocytes from the left ventricle of sham-operated mice.

Original language	English
Pages (from-to)	79-84
Number of pages	6
Journal	FEBS Letters
Volume	548
Issue number	1-3
Early online date	8 Jul 2003
DOIs	https://doi.org/10.1016/S0014-5793(03)00744-0
Publication status	Published - 31 Jul 2003
Externally published	Yes

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title = "Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF",

abstract = "The ribosomal DNA transcription-specific factor, UBF, is a key target for the regulation of ribosomal RNA synthesis and hypertrophic growth of isolated neonatal cardiomyocytes. In this study, we have examined whether UBF expression is also an important determinant of cardiac growth rates in vivo. We show that rDNA transcription, rRNA synthesis and UBF expression in left ventricular myocytes isolated from mice 1-6 weeks following transverse aortic constriction were significantly increased (2.5-3.5-fold) compared to the levels in myocytes from the left ventricle of sham-operated mice.",

keywords = "Cardiac hypertrophy, Left ventricular hypertrophy, Pressure overload, Ribosome, Upstream binding factor, rDNA transcription",

author = "Yves Brandenburger and Arthur, {Jane F.} and Woodcock, {Elizabeth A.} and Du, {Xiao Jun} and Gao, {Xiao Ming} and Autelitano, {Dominic J.} and Rothblum, {Lawrence I.} and Hannan, {Ross D.}",

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T1 - Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF

AU - Brandenburger, Yves

AU - Arthur, Jane F.

AU - Woodcock, Elizabeth A.

AU - Du, Xiao Jun

AU - Gao, Xiao Ming

AU - Autelitano, Dominic J.

AU - Rothblum, Lawrence I.

AU - Hannan, Ross D.

PY - 2003/7/31

Y1 - 2003/7/31

N2 - The ribosomal DNA transcription-specific factor, UBF, is a key target for the regulation of ribosomal RNA synthesis and hypertrophic growth of isolated neonatal cardiomyocytes. In this study, we have examined whether UBF expression is also an important determinant of cardiac growth rates in vivo. We show that rDNA transcription, rRNA synthesis and UBF expression in left ventricular myocytes isolated from mice 1-6 weeks following transverse aortic constriction were significantly increased (2.5-3.5-fold) compared to the levels in myocytes from the left ventricle of sham-operated mice.

AB - The ribosomal DNA transcription-specific factor, UBF, is a key target for the regulation of ribosomal RNA synthesis and hypertrophic growth of isolated neonatal cardiomyocytes. In this study, we have examined whether UBF expression is also an important determinant of cardiac growth rates in vivo. We show that rDNA transcription, rRNA synthesis and UBF expression in left ventricular myocytes isolated from mice 1-6 weeks following transverse aortic constriction were significantly increased (2.5-3.5-fold) compared to the levels in myocytes from the left ventricle of sham-operated mice.

KW - Cardiac hypertrophy

KW - Left ventricular hypertrophy

KW - Pressure overload

KW - Ribosome

KW - Upstream binding factor

KW - rDNA transcription

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DO - 10.1016/S0014-5793(03)00744-0

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VL - 548

SP - 79

EP - 84

JO - FEBS Letters

JF - FEBS Letters

IS - 1-3

ER -

Cardiac hypertrophy in vivo is associated with increased expression of the ribosomal gene transcription factor UBF

Abstract

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