Cardiovascular role of urotensin II: effect of chronic infusion in the rat

Andrew R. Kompa; Walter G. Thomas; Fiona See; Alex Tzanidis; Ross D. Hannan; Henry Krum

doi:10.1016/j.peptides.2004.03.029

Cardiovascular role of urotensin II: effect of chronic infusion in the rat

Andrew R. Kompa, Walter G. Thomas, Fiona See, Alex Tzanidis, Ross D. Hannan, Henry Krum^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

39 Citations (Scopus)

Abstract

Urotensin II (UII) is a potent vaso-active peptide thought to have multiple roles in the regulation of cardiovascular physiology and pathophysiology. The actions of UII are complex and difficult to interpret given its systemic hemodynamic effects and variable action on different vascular beds and isolated vessels. Direct effects of UII on the myocardium, include myocyte hypertrophy, extracellular matrix deposition and contractility. These observations, together with elevated plasma levels found in disease, are common traits reported in other pathophysiologically implicated neurohormonal systems. In this review, we include original data obtained from chronic infusion of UII in rats. We report a reduction in first derivative of left ventricular pressure (+dP/dt), as well as an increase in the ratio of left ventricular collagen I:III, that may contribute to the reduced myocardial contractility observed in these animals.

Original language	English
Pages (from-to)	1783-1788
Number of pages	6
Journal	Peptides
Volume	25
Issue number	10
DOIs	https://doi.org/10.1016/j.peptides.2004.03.029
Publication status	Published - Oct 2004
Externally published	Yes

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10.1016/j.peptides.2004.03.029

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title = "Cardiovascular role of urotensin II: effect of chronic infusion in the rat",

abstract = "Urotensin II (UII) is a potent vaso-active peptide thought to have multiple roles in the regulation of cardiovascular physiology and pathophysiology. The actions of UII are complex and difficult to interpret given its systemic hemodynamic effects and variable action on different vascular beds and isolated vessels. Direct effects of UII on the myocardium, include myocyte hypertrophy, extracellular matrix deposition and contractility. These observations, together with elevated plasma levels found in disease, are common traits reported in other pathophysiologically implicated neurohormonal systems. In this review, we include original data obtained from chronic infusion of UII in rats. We report a reduction in first derivative of left ventricular pressure (+dP/dt), as well as an increase in the ratio of left ventricular collagen I:III, that may contribute to the reduced myocardial contractility observed in these animals.",

keywords = "Extracellular matrix, Heart failure, Hemodynamics, Urotensin II, Vasoconstrictor peptide, Ventricular function",

author = "Kompa, {Andrew R.} and Thomas, {Walter G.} and Fiona See and Alex Tzanidis and Hannan, {Ross D.} and Henry Krum",

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T1 - Cardiovascular role of urotensin II: effect of chronic infusion in the rat

AU - Kompa, Andrew R.

AU - Thomas, Walter G.

AU - See, Fiona

AU - Tzanidis, Alex

AU - Hannan, Ross D.

AU - Krum, Henry

PY - 2004/10

Y1 - 2004/10

N2 - Urotensin II (UII) is a potent vaso-active peptide thought to have multiple roles in the regulation of cardiovascular physiology and pathophysiology. The actions of UII are complex and difficult to interpret given its systemic hemodynamic effects and variable action on different vascular beds and isolated vessels. Direct effects of UII on the myocardium, include myocyte hypertrophy, extracellular matrix deposition and contractility. These observations, together with elevated plasma levels found in disease, are common traits reported in other pathophysiologically implicated neurohormonal systems. In this review, we include original data obtained from chronic infusion of UII in rats. We report a reduction in first derivative of left ventricular pressure (+dP/dt), as well as an increase in the ratio of left ventricular collagen I:III, that may contribute to the reduced myocardial contractility observed in these animals.

AB - Urotensin II (UII) is a potent vaso-active peptide thought to have multiple roles in the regulation of cardiovascular physiology and pathophysiology. The actions of UII are complex and difficult to interpret given its systemic hemodynamic effects and variable action on different vascular beds and isolated vessels. Direct effects of UII on the myocardium, include myocyte hypertrophy, extracellular matrix deposition and contractility. These observations, together with elevated plasma levels found in disease, are common traits reported in other pathophysiologically implicated neurohormonal systems. In this review, we include original data obtained from chronic infusion of UII in rats. We report a reduction in first derivative of left ventricular pressure (+dP/dt), as well as an increase in the ratio of left ventricular collagen I:III, that may contribute to the reduced myocardial contractility observed in these animals.

KW - Extracellular matrix

KW - Heart failure

KW - Hemodynamics

KW - Urotensin II

KW - Vasoconstrictor peptide

KW - Ventricular function

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U2 - 10.1016/j.peptides.2004.03.029

DO - 10.1016/j.peptides.2004.03.029

M3 - Review article

SN - 0196-9781

VL - 25

SP - 1783

EP - 1788

JO - Peptides

JF - Peptides

IS - 10

ER -

Cardiovascular role of urotensin II: effect of chronic infusion in the rat

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