Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization

Anand Manoharan; Peter J. Rayner; Marianna Fekete; Wissam Iali; Philip Norcott; V. Hugh Perry; Simon B. Duckett

doi:10.1002/cphc.201800915

Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization

Anand Manoharan, Peter J. Rayner, Marianna Fekete, Wissam Iali, Philip Norcott, V. Hugh Perry, Simon B. Duckett^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.

Original language	English
Pages (from-to)	285-294
Number of pages	10
Journal	ChemPhysChem
Volume	20
Issue number	2
DOIs	https://doi.org/10.1002/cphc.201800915
Publication status	Published - 21 Jan 2019
Externally published	Yes

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abstract = "The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.",

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AU - Iali, Wissam

AU - Norcott, Philip

AU - Hugh Perry, V.

AU - Duckett, Simon B.

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AB - The hyperpolarization technique, Signal Amplification by Reversible Exchange (SABRE), has the potential to improve clinical diagnosis by making molecular magnetic resonance imaging in vivo a reality. Essential to this goal is the ability to produce a biocompatible bolus for administration. We seek here to determine how the identity of the catalyst and substrate affects the cytotoxicity by in vitro study, in addition to reporting how the use of biocompatible solvent mixtures influence the polarization transfer efficiency. By illustrating this across five catalysts and 8 substrates, we are able to identify routes to produce a bolus with minimal cytotoxic effects.

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ER -

Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization

Abstract

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