CD molecules 2005: Human cell differentiation molecules

Heddy Zola*, Bernadette Swart, Ian Nicholson, Bent Aasted, Armand Bensussan, Laurence Boumsell, Chris Buckley, Georgina Clark, Karel Drbal, Pablo Engel, Derek Hart, Václav Horejsí, Clare Isacke, Peter Macardle, Fabio Malavasi, David Mason, Daniel Olive, Armin Saalmueller, Stuart F. Schlossman, Reinhard Schwartz-AlbiezPaul Simmons, Thomas F. Tedder, Mariagrazia Uguccioni, Hilary Warren

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    102 Citations (Scopus)

    Abstract

    The immune system works through leukocytes interacting with each other, with other cells, with tissue matrices, with infectious agents, and with other antigens. These interactions are mediated by cell-surface glycoproteins and glycolipids. Antibodies against these leukocyte molecules have provided powerful tools for analysis of their structure, function, and distribution. Antibodies have been used widely in hematology, immunology, and pathology, and in research, diagnosis, and therapy. The associated CD nomenclature is commonly used when referring to leukocyte surface molecules and antibodies against them. It provides an essential classification for diagnostic and therapeutic purposes. The most recent (8th) Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), held in Adelaide, Australia, in December 2004, allocated 95 new CD designations and made radical changes to its aims and future operational strategy in order to maintain its relevance to modern human biology and clinical practice.

    Original languageEnglish
    Pages (from-to)3123-3126
    Number of pages4
    JournalBlood
    Volume106
    Issue number9
    DOIs
    Publication statusPublished - Nov 2005

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