Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus

Clarence J. Fernandes; Lorna A. Fernandes; Peter Collignon; Susan Bradbury; Thomas Gottlieb; Glenn Funnell; Sue Tiley; Ian Winney; James Branley; Sam Ryder; Iain B. Gosbell; Helen Ziochos; Alistair McGregor; Rob Peterson; David Mitchell

doi:10.1093/jac/dki052

Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus

Clarence J. Fernandes, Lorna A. Fernandes, Peter Collignon^*, Susan Bradbury, Thomas Gottlieb, Glenn Funnell, Sue Tiley, Ian Winney, James Branley, Sam Ryder, Iain B. Gosbell, Helen Ziochos, Alistair McGregor, Rob Peterson, David Mitchell

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

108 Citations (Scopus)

Abstract

Objectives: To evaluate the usefulness of cefoxitin when used as a surrogate marker for the detection of methicillin resistance. Patients and methods: Eight hundred and seventy-one strains of Staphylococcus aureus, collected from eight tertiary referral centres serving diverse socio-economic populations, were included in the study using NCCLS disc diffusion and the agar dilution methods. Results: Using cefoxitin and NCCLS criteria for disc diffusion, the sensitivity and specificity for recognizing methicillin resistance were both 100%. Similar results were obtained when the strains were tested by the agar dilution method. The cefoxitin MICs for methicillin-susceptible strains were ≤ 4 mg/L. Conclusions: Testing with cefoxitin as a surrogate marker for the detection of methicillin resistance was very accurate with both disc diffusion and agar dilution methods. Such testing clearly distinguished methicillin-resistant strains of S. aureus from methicillin-susceptible strains.

Original language	English
Pages (from-to)	506-510
Number of pages	5
Journal	Journal of Antimicrobial Chemotherapy
Volume	55
Issue number	4
DOIs	https://doi.org/10.1093/jac/dki052
Publication status	Published - Apr 2005
Externally published	Yes

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Fernandes, C. J., Fernandes, L. A., Collignon, P., Bradbury, S., Gottlieb, T., Funnell, G., Tiley, S., Winney, I., Branley, J., Ryder, S., Gosbell, I. B., Ziochos, H., McGregor, A., Peterson, R., & Mitchell, D. (2005). Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, 55(4), 506-510. https://doi.org/10.1093/jac/dki052

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title = "Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus",

abstract = "Objectives: To evaluate the usefulness of cefoxitin when used as a surrogate marker for the detection of methicillin resistance. Patients and methods: Eight hundred and seventy-one strains of Staphylococcus aureus, collected from eight tertiary referral centres serving diverse socio-economic populations, were included in the study using NCCLS disc diffusion and the agar dilution methods. Results: Using cefoxitin and NCCLS criteria for disc diffusion, the sensitivity and specificity for recognizing methicillin resistance were both 100%. Similar results were obtained when the strains were tested by the agar dilution method. The cefoxitin MICs for methicillin-susceptible strains were ≤ 4 mg/L. Conclusions: Testing with cefoxitin as a surrogate marker for the detection of methicillin resistance was very accurate with both disc diffusion and agar dilution methods. Such testing clearly distinguished methicillin-resistant strains of S. aureus from methicillin-susceptible strains.",

keywords = "Community-onset MRSA infections, Hospital-acquired infections, Non-multiresistant staphylococcus aureus, Oxacillin resistance",

author = "Fernandes, {Clarence J.} and Fernandes, {Lorna A.} and Peter Collignon and Susan Bradbury and Thomas Gottlieb and Glenn Funnell and Sue Tiley and Ian Winney and James Branley and Sam Ryder and Gosbell, {Iain B.} and Helen Ziochos and Alistair McGregor and Rob Peterson and David Mitchell",

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doi = "10.1093/jac/dki052",

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volume = "55",

pages = "506--510",

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Fernandes, CJ, Fernandes, LA, Collignon, P, Bradbury, S, Gottlieb, T, Funnell, G, Tiley, S, Winney, I, Branley, J, Ryder, S, Gosbell, IB, Ziochos, H, McGregor, A, Peterson, R & Mitchell, D 2005, 'Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus', Journal of Antimicrobial Chemotherapy, vol. 55, no. 4, pp. 506-510. https://doi.org/10.1093/jac/dki052

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T1 - Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus

AU - Fernandes, Clarence J.

AU - Fernandes, Lorna A.

AU - Collignon, Peter

AU - Bradbury, Susan

AU - Gottlieb, Thomas

AU - Funnell, Glenn

AU - Tiley, Sue

AU - Winney, Ian

AU - Branley, James

AU - Ryder, Sam

AU - Gosbell, Iain B.

AU - Ziochos, Helen

AU - McGregor, Alistair

AU - Peterson, Rob

AU - Mitchell, David

PY - 2005/4

Y1 - 2005/4

N2 - Objectives: To evaluate the usefulness of cefoxitin when used as a surrogate marker for the detection of methicillin resistance. Patients and methods: Eight hundred and seventy-one strains of Staphylococcus aureus, collected from eight tertiary referral centres serving diverse socio-economic populations, were included in the study using NCCLS disc diffusion and the agar dilution methods. Results: Using cefoxitin and NCCLS criteria for disc diffusion, the sensitivity and specificity for recognizing methicillin resistance were both 100%. Similar results were obtained when the strains were tested by the agar dilution method. The cefoxitin MICs for methicillin-susceptible strains were ≤ 4 mg/L. Conclusions: Testing with cefoxitin as a surrogate marker for the detection of methicillin resistance was very accurate with both disc diffusion and agar dilution methods. Such testing clearly distinguished methicillin-resistant strains of S. aureus from methicillin-susceptible strains.

AB - Objectives: To evaluate the usefulness of cefoxitin when used as a surrogate marker for the detection of methicillin resistance. Patients and methods: Eight hundred and seventy-one strains of Staphylococcus aureus, collected from eight tertiary referral centres serving diverse socio-economic populations, were included in the study using NCCLS disc diffusion and the agar dilution methods. Results: Using cefoxitin and NCCLS criteria for disc diffusion, the sensitivity and specificity for recognizing methicillin resistance were both 100%. Similar results were obtained when the strains were tested by the agar dilution method. The cefoxitin MICs for methicillin-susceptible strains were ≤ 4 mg/L. Conclusions: Testing with cefoxitin as a surrogate marker for the detection of methicillin resistance was very accurate with both disc diffusion and agar dilution methods. Such testing clearly distinguished methicillin-resistant strains of S. aureus from methicillin-susceptible strains.

KW - Community-onset MRSA infections

KW - Hospital-acquired infections

KW - Non-multiresistant staphylococcus aureus

KW - Oxacillin resistance

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U2 - 10.1093/jac/dki052

DO - 10.1093/jac/dki052

M3 - Article

SN - 0305-7453

VL - 55

SP - 506

EP - 510

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 4

ER -

Cefoxitin resistance as a surrogate marker for the detection of methicillin-resistant Staphylococcus aureus

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