Cellular and genetic mechanisms of self tolerance and autoimmunity

Christopher C. Goodnow*, Jonathon Sprent, Barbara Fazekas Barbara, Carola G. Vinuesa

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    563 Citations (Scopus)

    Abstract

    The mammalian immune system has an extraordinary potential for making receptors that sense and neutralize any chemical entity entering the body. Inevitably, some of these receptors recognize components of our own body, and so cellular mechanisms have evolved to control the activity of these 'forbidden' receptors and achieve immunological self tolerance. Many of the genes and proteins involved are conserved between humans and other mammals. This provides the bridge between clinical studies and mechanisms defined in experimental animals to understand how sets of gene products coordinate self-tolerance mechanisms and how defects in these controls lead to autoimmune disease.

    Original languageEnglish
    Pages (from-to)590-597
    Number of pages8
    JournalNature
    Volume435
    Issue number7042
    DOIs
    Publication statusPublished - 2 Jun 2005

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