Cellular and molecular regulation of eosinophil trafficking to the lung

Simon P. Hogan; Arne W. Mould; Janine M. Young; Marc E. Rothenberg; Alistair J. Ramsay; Klaus Matthaei; Ian G. Young; Paul S. Foster

doi:10.1046/j.1440-1711.1998.00766.x

Cellular and molecular regulation of eosinophil trafficking to the lung

Simon P. Hogan, Arne W. Mould, Janine M. Young, Marc E. Rothenberg, Alistair J. Ramsay, Klaus Matthaei, Ian G. Young, Paul S. Foster^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Airway inflammation is central to the pathogenesis of allergic asthma, and molecules that mediate this process obviously represent targets for therapy. In the present article, we discuss our experiments, which point to CD4⁺ T cells and IL-5-driven eosinophilia as potential targets for the relief of bronchial hyperractivity in late-phase asthma.

Original language	English
Pages (from-to)	454-460
Number of pages	7
Journal	Immunology and Cell Biology
Volume	76
Issue number	5
DOIs	https://doi.org/10.1046/j.1440-1711.1998.00766.x
Publication status	Published - 1998

Access to Document

10.1046/j.1440-1711.1998.00766.x

Cite this

@article{27259bcb9568435e86315a56cf7b321d,

title = "Cellular and molecular regulation of eosinophil trafficking to the lung",

abstract = "Airway inflammation is central to the pathogenesis of allergic asthma, and molecules that mediate this process obviously represent targets for therapy. In the present article, we discuss our experiments, which point to CD4+ T cells and IL-5-driven eosinophilia as potential targets for the relief of bronchial hyperractivity in late-phase asthma.",

keywords = "CD4 T lymphocytes and eosinophils, Eotaxin, Interleukin-4, Interleukin-5",

author = "Hogan, {Simon P.} and Mould, {Arne W.} and Young, {Janine M.} and Rothenberg, {Marc E.} and Ramsay, {Alistair J.} and Klaus Matthaei and Young, {Ian G.} and Foster, {Paul S.}",

year = "1998",

doi = "10.1046/j.1440-1711.1998.00766.x",

language = "English",

volume = "76",

pages = "454--460",

journal = "Immunology and Cell Biology",

issn = "0818-9641",

publisher = "John Wiley & Sons Inc.",

number = "5",

}

TY - JOUR

T1 - Cellular and molecular regulation of eosinophil trafficking to the lung

AU - Hogan, Simon P.

AU - Mould, Arne W.

AU - Young, Janine M.

AU - Rothenberg, Marc E.

AU - Ramsay, Alistair J.

AU - Matthaei, Klaus

AU - Young, Ian G.

AU - Foster, Paul S.

PY - 1998

Y1 - 1998

N2 - Airway inflammation is central to the pathogenesis of allergic asthma, and molecules that mediate this process obviously represent targets for therapy. In the present article, we discuss our experiments, which point to CD4+ T cells and IL-5-driven eosinophilia as potential targets for the relief of bronchial hyperractivity in late-phase asthma.

AB - Airway inflammation is central to the pathogenesis of allergic asthma, and molecules that mediate this process obviously represent targets for therapy. In the present article, we discuss our experiments, which point to CD4+ T cells and IL-5-driven eosinophilia as potential targets for the relief of bronchial hyperractivity in late-phase asthma.

KW - CD4 T lymphocytes and eosinophils

KW - Eotaxin

KW - Interleukin-4

KW - Interleukin-5

UR - http://www.scopus.com/inward/record.url?scp=0031759355&partnerID=8YFLogxK

U2 - 10.1046/j.1440-1711.1998.00766.x

DO - 10.1046/j.1440-1711.1998.00766.x

M3 - Article

SN - 0818-9641

VL - 76

SP - 454

EP - 460

JO - Immunology and Cell Biology

JF - Immunology and Cell Biology

IS - 5

ER -

Cellular and molecular regulation of eosinophil trafficking to the lung

Abstract

Access to Document

Other files and links

Fingerprint

Cite this