Change in cognitive functioning associated with ApoE genotype in a community sample of older adults

Scott M. Hofer; Helen Christensen; Andrew J. Mackinnon; Ailsa E. Korten; Anthony F. Jorm; Alexander S. Henderson; Simon Easteal

doi:10.1037/0882-7974.17.2.194

Change in cognitive functioning associated with ApoE genotype in a community sample of older adults

Scott M. Hofer^*, Helen Christensen, Andrew J. Mackinnon, Ailsa E. Korten, Anthony F. Jorm, Alexander S. Henderson, Simon Easteal

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

The influence of a genetic risk factor, apolipoprotein E (apoE) ε4 variant, was assessed in older adults aged 70 to 94 on 3 occasions over 7 years. The results of latent growth curve analyses are reported for individuals genotyped for apoE at the 2nd measurement occasion (n = 601) and for a subsample of individuals without probable or definite dementia during the 1st or 2nd occasion (n = 434). ApoE-ε4 status was a significant predictor of level and change in memory performance and change in speed performance in the full sample, and of initial level and change in memory performance in the nondemented subsample. These results support previous findings that apoE-ε4 is associated with accelerated memory deterioration in individuals without clinical dementia.

Original language	English
Pages (from-to)	194-208
Number of pages	15
Journal	Psychology and Aging
Volume	17
Issue number	2
DOIs	https://doi.org/10.1037/0882-7974.17.2.194
Publication status	Published - 2002

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title = "Change in cognitive functioning associated with ApoE genotype in a community sample of older adults",

abstract = "The influence of a genetic risk factor, apolipoprotein E (apoE) ε4 variant, was assessed in older adults aged 70 to 94 on 3 occasions over 7 years. The results of latent growth curve analyses are reported for individuals genotyped for apoE at the 2nd measurement occasion (n = 601) and for a subsample of individuals without probable or definite dementia during the 1st or 2nd occasion (n = 434). ApoE-ε4 status was a significant predictor of level and change in memory performance and change in speed performance in the full sample, and of initial level and change in memory performance in the nondemented subsample. These results support previous findings that apoE-ε4 is associated with accelerated memory deterioration in individuals without clinical dementia.",

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AU - Hofer, Scott M.

AU - Christensen, Helen

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AU - Jorm, Anthony F.

AU - Henderson, Alexander S.

AU - Easteal, Simon

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N2 - The influence of a genetic risk factor, apolipoprotein E (apoE) ε4 variant, was assessed in older adults aged 70 to 94 on 3 occasions over 7 years. The results of latent growth curve analyses are reported for individuals genotyped for apoE at the 2nd measurement occasion (n = 601) and for a subsample of individuals without probable or definite dementia during the 1st or 2nd occasion (n = 434). ApoE-ε4 status was a significant predictor of level and change in memory performance and change in speed performance in the full sample, and of initial level and change in memory performance in the nondemented subsample. These results support previous findings that apoE-ε4 is associated with accelerated memory deterioration in individuals without clinical dementia.

AB - The influence of a genetic risk factor, apolipoprotein E (apoE) ε4 variant, was assessed in older adults aged 70 to 94 on 3 occasions over 7 years. The results of latent growth curve analyses are reported for individuals genotyped for apoE at the 2nd measurement occasion (n = 601) and for a subsample of individuals without probable or definite dementia during the 1st or 2nd occasion (n = 434). ApoE-ε4 status was a significant predictor of level and change in memory performance and change in speed performance in the full sample, and of initial level and change in memory performance in the nondemented subsample. These results support previous findings that apoE-ε4 is associated with accelerated memory deterioration in individuals without clinical dementia.

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JO - Psychology and Aging

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Change in cognitive functioning associated with ApoE genotype in a community sample of older adults

Abstract

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