TY - JOUR
T1 - Characteristics and causes of death in children with neonatal abstinence syndrome
AU - Uebel, Hannah
AU - Wright, Ian M.
AU - Burns, Lucinda
AU - Hilder, Lisa
AU - Bajuk, Barbara
AU - Breen, Courtney
AU - Abdel-Latif, Mohamed E.
AU - Falconer, Janet
AU - Clews, Sarah
AU - Ward, Meredith
AU - Eastwood, John
AU - Oei, Ju Lee
N1 - Publisher Copyright:
© 2020 Paediatrics and Child Health Division (The Royal Australasian College of Physicians)
PY - 2020/12
Y1 - 2020/12
N2 - Aim: To determine characteristics of death in children with neonatal abstinence syndrome (NAS). Methods: A population-based linkage study of children from birth to 13 years of age in New South Wales (NSW), Australia, born 1 July 2000 to 31 December 2011. Infants with an International Statistical Classification of Diseases and Related Problems, Australian modification coding of NAS (P96.1, n = 3842) were compared to infants (n = 1 018 421) without NAS by birth, hospitalisation and death records linkage. Results: Forty-five (1.2%) children with NAS died, compared to 3665 (0.4%) other children. Most deaths (n = 30, 66%) in NAS children occurred between 1 month and 1 year. Risk of death was independently increased in full-term children (hazard ratio 2.34, 95% confidence interval 1.63–3.35; P < 0.001) from lower socio-economic groups (1.23, 1.12–1.35; P < 0.001), most commonly from ill-defined or external causes, including assault and accidents (P < 0.001). Conclusions: Children with NAS, especially those of term gestation and from lower socio-economic groups, are more likely to die, especially from external causes.
AB - Aim: To determine characteristics of death in children with neonatal abstinence syndrome (NAS). Methods: A population-based linkage study of children from birth to 13 years of age in New South Wales (NSW), Australia, born 1 July 2000 to 31 December 2011. Infants with an International Statistical Classification of Diseases and Related Problems, Australian modification coding of NAS (P96.1, n = 3842) were compared to infants (n = 1 018 421) without NAS by birth, hospitalisation and death records linkage. Results: Forty-five (1.2%) children with NAS died, compared to 3665 (0.4%) other children. Most deaths (n = 30, 66%) in NAS children occurred between 1 month and 1 year. Risk of death was independently increased in full-term children (hazard ratio 2.34, 95% confidence interval 1.63–3.35; P < 0.001) from lower socio-economic groups (1.23, 1.12–1.35; P < 0.001), most commonly from ill-defined or external causes, including assault and accidents (P < 0.001). Conclusions: Children with NAS, especially those of term gestation and from lower socio-economic groups, are more likely to die, especially from external causes.
KW - childhood mortality
KW - linkage
KW - neonatal abstinence syndrome
UR - https://www.scopus.com/pages/publications/85089596219
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=anu_research_portal_plus2&SrcAuth=WosAPI&KeyUT=WOS:000560814300001&DestLinkType=FullRecord&DestApp=WOS_CPL
U2 - 10.1111/jpc.15091
DO - 10.1111/jpc.15091
M3 - Article
C2 - 32815631
SN - 1034-4810
VL - 56
SP - 1933
EP - 1940
JO - Journal of Paediatrics and Child Health
JF - Journal of Paediatrics and Child Health
IS - 12
ER -