TY - JOUR
T1 - Characterization, chromosomal location, and genomic neighborhood of a ratite ortholog of a gene with gonadal expression in mammals
AU - Janes, Daniel E.
AU - Ezaz, Tariq
AU - Graves, Jennifer A.Marshall
AU - Edwards, Scott V.
PY - 2008/10
Y1 - 2008/10
N2 - A locus that we name SubA was discovered during large-scale sequencing and characterization of a bacterial artificial chromosome library from an emu, Dromaius novaehollandiae. This locus yields a significantly negative Tajimas D in emus and is conserved across emu, chicken, mouse, and human. Expression of SubA orthologs has been reported in human ovaries and in mouse testes, but remains unknown in emus. The locus was physically mapped onto a pair of microchromosomes in emus by fluorescent in situ hybridization and also in chicken as previously reported. By characterizing emu SubA in this article, we aim to improve current descriptions of the cascade of genes associated with avian sex differentiation. Future experimentation will report the expression of SubA in ratites, other birds, and nonavian reptiles.
AB - A locus that we name SubA was discovered during large-scale sequencing and characterization of a bacterial artificial chromosome library from an emu, Dromaius novaehollandiae. This locus yields a significantly negative Tajimas D in emus and is conserved across emu, chicken, mouse, and human. Expression of SubA orthologs has been reported in human ovaries and in mouse testes, but remains unknown in emus. The locus was physically mapped onto a pair of microchromosomes in emus by fluorescent in situ hybridization and also in chicken as previously reported. By characterizing emu SubA in this article, we aim to improve current descriptions of the cascade of genes associated with avian sex differentiation. Future experimentation will report the expression of SubA in ratites, other birds, and nonavian reptiles.
UR - http://www.scopus.com/inward/record.url?scp=53549099932&partnerID=8YFLogxK
U2 - 10.1093/icb/icn024
DO - 10.1093/icb/icn024
M3 - Article
SN - 1540-7063
VL - 48
SP - 505
EP - 511
JO - Integrative and Comparative Biology
JF - Integrative and Comparative Biology
IS - 4
ER -