Characterization, chromosomal location, and genomic neighborhood of a ratite ortholog of a gene with gonadal expression in mammals

Daniel E. Janes, Tariq Ezaz, Jennifer A.Marshall Graves, Scott V. Edwards

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    A locus that we name SubA was discovered during large-scale sequencing and characterization of a bacterial artificial chromosome library from an emu, Dromaius novaehollandiae. This locus yields a significantly negative Tajimas D in emus and is conserved across emu, chicken, mouse, and human. Expression of SubA orthologs has been reported in human ovaries and in mouse testes, but remains unknown in emus. The locus was physically mapped onto a pair of microchromosomes in emus by fluorescent in situ hybridization and also in chicken as previously reported. By characterizing emu SubA in this article, we aim to improve current descriptions of the cascade of genes associated with avian sex differentiation. Future experimentation will report the expression of SubA in ratites, other birds, and nonavian reptiles.

    Original languageEnglish
    Pages (from-to)505-511
    Number of pages7
    JournalIntegrative and Comparative Biology
    Volume48
    Issue number4
    DOIs
    Publication statusPublished - Oct 2008

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