Chemical composition and antimicrobial activity of essential oil isolated from the cultured mycelia of Ganoderma japonicum

Dandan Liu; Zheng Hu; Zhigang Liu; Bo Yang; Wenjuan Tu; Liang Li

doi:10.1016/S1007-4376(09)60049-6

Chemical composition and antimicrobial activity of essential oil isolated from the cultured mycelia of Ganoderma japonicum

Dandan Liu, Zheng Hu^*, Zhigang Liu, Bo Yang, Wenjuan Tu, Liang Li

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Objective: To explore a new natural antibiotic. Methods: The chemical composition of the essential oil from Ganoderma japonicum (G. japonicum) mycelia was analyzed by gas chromatography-mass spectrometry(GC-MS). The antimicrobial activity of the oil was evaluated against eighteen microorganisms, including bacteria, mildew and yeast by using a disc diffusion method. Furthermore, the minimum inhibitory concentrations(MIC) and the minimum bactericidal concentrations(MBC) of the essential oil against twelve clinical pathogens were determined. Results: The main components of the oil were nerolidol, decadienal, linalool and benzyl alcohol. The antimicrobial results indicated that the oil inhibited all the tested bacterium, especially Methicillin-resistant Staphylococcus aureus (MRSA) in which the antibacterial activity exhibited a MBC of 1.03 mg/ml. Conclusion: The essential oil of G. japonicum mycelium has significant inhibitory activity. It is a potential medicinal resource that can be used as a natural antibiotic.

Original language	English
Pages (from-to)	168-172
Number of pages	5
Journal	Journal of Nanjing Medical University
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/S1007-4376(09)60049-6
Publication status	Published - May 2009

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title = "Chemical composition and antimicrobial activity of essential oil isolated from the cultured mycelia of Ganoderma japonicum",

abstract = "Objective: To explore a new natural antibiotic. Methods: The chemical composition of the essential oil from Ganoderma japonicum (G. japonicum) mycelia was analyzed by gas chromatography-mass spectrometry(GC-MS). The antimicrobial activity of the oil was evaluated against eighteen microorganisms, including bacteria, mildew and yeast by using a disc diffusion method. Furthermore, the minimum inhibitory concentrations(MIC) and the minimum bactericidal concentrations(MBC) of the essential oil against twelve clinical pathogens were determined. Results: The main components of the oil were nerolidol, decadienal, linalool and benzyl alcohol. The antimicrobial results indicated that the oil inhibited all the tested bacterium, especially Methicillin-resistant Staphylococcus aureus (MRSA) in which the antibacterial activity exhibited a MBC of 1.03 mg/ml. Conclusion: The essential oil of G. japonicum mycelium has significant inhibitory activity. It is a potential medicinal resource that can be used as a natural antibiotic.",

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author = "Dandan Liu and Zheng Hu and Zhigang Liu and Bo Yang and Wenjuan Tu and Liang Li",

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T1 - Chemical composition and antimicrobial activity of essential oil isolated from the cultured mycelia of Ganoderma japonicum

AU - Liu, Dandan

AU - Hu, Zheng

AU - Liu, Zhigang

AU - Yang, Bo

AU - Tu, Wenjuan

AU - Li, Liang

PY - 2009/5

Y1 - 2009/5

N2 - Objective: To explore a new natural antibiotic. Methods: The chemical composition of the essential oil from Ganoderma japonicum (G. japonicum) mycelia was analyzed by gas chromatography-mass spectrometry(GC-MS). The antimicrobial activity of the oil was evaluated against eighteen microorganisms, including bacteria, mildew and yeast by using a disc diffusion method. Furthermore, the minimum inhibitory concentrations(MIC) and the minimum bactericidal concentrations(MBC) of the essential oil against twelve clinical pathogens were determined. Results: The main components of the oil were nerolidol, decadienal, linalool and benzyl alcohol. The antimicrobial results indicated that the oil inhibited all the tested bacterium, especially Methicillin-resistant Staphylococcus aureus (MRSA) in which the antibacterial activity exhibited a MBC of 1.03 mg/ml. Conclusion: The essential oil of G. japonicum mycelium has significant inhibitory activity. It is a potential medicinal resource that can be used as a natural antibiotic.

AB - Objective: To explore a new natural antibiotic. Methods: The chemical composition of the essential oil from Ganoderma japonicum (G. japonicum) mycelia was analyzed by gas chromatography-mass spectrometry(GC-MS). The antimicrobial activity of the oil was evaluated against eighteen microorganisms, including bacteria, mildew and yeast by using a disc diffusion method. Furthermore, the minimum inhibitory concentrations(MIC) and the minimum bactericidal concentrations(MBC) of the essential oil against twelve clinical pathogens were determined. Results: The main components of the oil were nerolidol, decadienal, linalool and benzyl alcohol. The antimicrobial results indicated that the oil inhibited all the tested bacterium, especially Methicillin-resistant Staphylococcus aureus (MRSA) in which the antibacterial activity exhibited a MBC of 1.03 mg/ml. Conclusion: The essential oil of G. japonicum mycelium has significant inhibitory activity. It is a potential medicinal resource that can be used as a natural antibiotic.

KW - Ganoderma japonicum

KW - antimicrobial activity

KW - clinical pathogens

KW - essential oil

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DO - 10.1016/S1007-4376(09)60049-6

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EP - 172

JO - Journal of Nanjing Medical University

JF - Journal of Nanjing Medical University

IS - 3

ER -

Chemical composition and antimicrobial activity of essential oil isolated from the cultured mycelia of Ganoderma japonicum

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