Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F

Jiri Mikusek; Jeremy Nugent; Ping Lan; Martin G. Banwell

doi:10.1021/acs.jnatprod.8b00778

Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F

Jiri Mikusek, Jeremy Nugent, Ping Lan, Martin G. Banwell^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A total synthesis of compound 3 from p-bromophenol is reported and thereby establishing that this, rather than its cyclodehydrated counterpart 1 (as postulated originally), is the correct structure of the natural product myrsinoic acid F. The biological evaluation of compound 3 in a mouse-ear edema assay established that it is a significantly more potent anti-inflammatory agent than the NSAID indometacin.

Original language	English
Pages (from-to)	96-100
Number of pages	5
Journal	Journal of Natural Products
Volume	82
Issue number	1
DOIs	https://doi.org/10.1021/acs.jnatprod.8b00778
Publication status	Published - 25 Jan 2019

Access to Document

10.1021/acs.jnatprod.8b00778

Cite this

@article{53e2f88c6efe43f6bb99bc44ff36e4bc,

title = "Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F",

abstract = "A total synthesis of compound 3 from p-bromophenol is reported and thereby establishing that this, rather than its cyclodehydrated counterpart 1 (as postulated originally), is the correct structure of the natural product myrsinoic acid F. The biological evaluation of compound 3 in a mouse-ear edema assay established that it is a significantly more potent anti-inflammatory agent than the NSAID indometacin.",

author = "Jiri Mikusek and Jeremy Nugent and Ping Lan and Banwell, {Martin G.}",

note = "Publisher Copyright: {\textcopyright} 2018 American Chemical Society and American Society of Pharmacognosy.",

year = "2019",

month = jan,

day = "25",

doi = "10.1021/acs.jnatprod.8b00778",

language = "English",

volume = "82",

pages = "96--100",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "1",

}

TY - JOUR

T1 - Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F

AU - Mikusek, Jiri

AU - Nugent, Jeremy

AU - Lan, Ping

AU - Banwell, Martin G.

PY - 2019/1/25

Y1 - 2019/1/25

N2 - A total synthesis of compound 3 from p-bromophenol is reported and thereby establishing that this, rather than its cyclodehydrated counterpart 1 (as postulated originally), is the correct structure of the natural product myrsinoic acid F. The biological evaluation of compound 3 in a mouse-ear edema assay established that it is a significantly more potent anti-inflammatory agent than the NSAID indometacin.

AB - A total synthesis of compound 3 from p-bromophenol is reported and thereby establishing that this, rather than its cyclodehydrated counterpart 1 (as postulated originally), is the correct structure of the natural product myrsinoic acid F. The biological evaluation of compound 3 in a mouse-ear edema assay established that it is a significantly more potent anti-inflammatory agent than the NSAID indometacin.

UR - http://www.scopus.com/inward/record.url?scp=85060525522&partnerID=8YFLogxK

U2 - 10.1021/acs.jnatprod.8b00778

DO - 10.1021/acs.jnatprod.8b00778

M3 - Article

SN - 0163-3864

VL - 82

SP - 96

EP - 100

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 1

ER -

Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F

Abstract

Access to Document

Other files and links

Fingerprint

Cite this