Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F

Jiri Mikusek; Jeremy Nugent; Ping Lan; Martin G. Banwell

doi:10.1021/acs.jnatprod.8b00778

Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F

Jiri Mikusek, Jeremy Nugent, Ping Lan, Martin G. Banwell^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A total synthesis of compound 3 from p-bromophenol is reported and thereby establishing that this, rather than its cyclodehydrated counterpart 1 (as postulated originally), is the correct structure of the natural product myrsinoic acid F. The biological evaluation of compound 3 in a mouse-ear edema assay established that it is a significantly more potent anti-inflammatory agent than the NSAID indometacin.

Original language	English
Pages (from-to)	96-100
Number of pages	5
Journal	Journal of Natural Products
Volume	82
Issue number	1
DOIs	https://doi.org/10.1021/acs.jnatprod.8b00778
Publication status	Published - 25 Jan 2019

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10.1021/acs.jnatprod.8b00778

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title = "Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F",

abstract = "A total synthesis of compound 3 from p-bromophenol is reported and thereby establishing that this, rather than its cyclodehydrated counterpart 1 (as postulated originally), is the correct structure of the natural product myrsinoic acid F. The biological evaluation of compound 3 in a mouse-ear edema assay established that it is a significantly more potent anti-inflammatory agent than the NSAID indometacin.",

author = "Jiri Mikusek and Jeremy Nugent and Ping Lan and Banwell, \{Martin G.\}",

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AU - Mikusek, Jiri

AU - Nugent, Jeremy

AU - Lan, Ping

AU - Banwell, Martin G.

PY - 2019/1/25

Y1 - 2019/1/25

N2 - A total synthesis of compound 3 from p-bromophenol is reported and thereby establishing that this, rather than its cyclodehydrated counterpart 1 (as postulated originally), is the correct structure of the natural product myrsinoic acid F. The biological evaluation of compound 3 in a mouse-ear edema assay established that it is a significantly more potent anti-inflammatory agent than the NSAID indometacin.

AB - A total synthesis of compound 3 from p-bromophenol is reported and thereby establishing that this, rather than its cyclodehydrated counterpart 1 (as postulated originally), is the correct structure of the natural product myrsinoic acid F. The biological evaluation of compound 3 in a mouse-ear edema assay established that it is a significantly more potent anti-inflammatory agent than the NSAID indometacin.

UR - https://www.scopus.com/pages/publications/85060525522

U2 - 10.1021/acs.jnatprod.8b00778

DO - 10.1021/acs.jnatprod.8b00778

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EP - 100

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 1

ER -

Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F

Abstract

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