Chemoenzymatic approaches to lycorine-type amaryllidaceae alkaloids: Total syntheses of enf-lycoricidine, 3-epi-ent-lycoricidine, and 4-deoxy-3-epi-ent- lycoricidine

Maria Matveenko, Okanya J. Kokas, Martin G. Banwell*, Anthony C. Willis

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    71 Citations (Scopus)

    Abstract

    The readily available and enzymatically derived cis-1,2-dihydrocatechol 4 has been elaborated, over 11 steps including an Overman rearrangement, into the non-natural enantiomer, (-)-1, of the alkaloid lycoricidine [(+)-1]. Related chemistries have provided analogues 18, 19, and 26.

    Original languageEnglish
    Pages (from-to)3683-3685
    Number of pages3
    JournalOrganic Letters
    Volume9
    Issue number18
    DOIs
    Publication statusPublished - 30 Aug 2007

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