Chemoenzymatic approaches to the montanine alkaloids: A total synthesis of (+)-brunsvigine

Martin G. Banwell; Okanya J. Kokas; Anthony C. Willis

doi:10.1021/ol071344y

Chemoenzymatic approaches to the montanine alkaloids: A total synthesis of (+)-brunsvigine

Martin G. Banwell^*, Okanya J. Kokas, Anthony C. Willis

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

The readily available and enzymatically derived cis-1,2-dihydrocatechols 3a and 3b have been elaborated over 17 steps, including a novel radical addition/elimination sequence, into the enantiomer, (+)-1, of the montanine alkaloid brunsvigine [(-)-1].

Original language	English
Pages (from-to)	3503-3506
Number of pages	4
Journal	Organic Letters
Volume	9
Issue number	18
DOIs	https://doi.org/10.1021/ol071344y
Publication status	Published - 30 Aug 2007

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title = "Chemoenzymatic approaches to the montanine alkaloids: A total synthesis of (+)-brunsvigine",

abstract = "The readily available and enzymatically derived cis-1,2-dihydrocatechols 3a and 3b have been elaborated over 17 steps, including a novel radical addition/elimination sequence, into the enantiomer, (+)-1, of the montanine alkaloid brunsvigine [(-)-1].",

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AU - Willis, Anthony C.

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AB - The readily available and enzymatically derived cis-1,2-dihydrocatechols 3a and 3b have been elaborated over 17 steps, including a novel radical addition/elimination sequence, into the enantiomer, (+)-1, of the montanine alkaloid brunsvigine [(-)-1].

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JO - Organic Letters

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Chemoenzymatic approaches to the montanine alkaloids: A total synthesis of (+)-brunsvigine

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